師資
個(gè)人簡介：
劉星吟,，南方科技大學(xué)醫(yī)學(xué)院生物化學(xué)系教授, 腸道微生態(tài)研究領(lǐng)域的學(xué)術(shù)帶頭人；2023年入選中國生物物理學(xué)會(huì)優(yōu)秀女科學(xué)家稱號(hào),；2024年入選Cell Press最有影響力,，最受歡迎的中國作者稱號(hào),；劉星吟教授現(xiàn)擔(dān)任Microbiological Research, iMeta等多本國際雜志副主編,、編委,。Cell Host & Microbe,、Gut、Cell Genomics,、Cell Reports,、Cell Reports Medicine, Gut、Microbiome,、Gut Microbes等30余本國際權(quán)威雜志審稿人及特邀編輯,。已發(fā)表SCI收錄論文近60余篇，其中作為通訊或第一作者在 Cell Host & Microbe, Cell Metabolism, Gut, Gut Microbes,、Cell Reports,、Npj Biofilm & Microbiome、 Genome Medicine 等知名權(quán)威雜志上發(fā)表論文近40余篇,，授權(quán)專利8項(xiàng),，轉(zhuǎn)化2項(xiàng)。
研究領(lǐng)域：
微生態(tài)在神經(jīng)系統(tǒng)疾病和腫瘤發(fā)生發(fā)展中的作用及機(jī)制研究
腸道微生物對神經(jīng)免疫的調(diào)控機(jī)制
天然益生菌篩選和功能挖掘
合成生物學(xué)-靶向治療疾病的新型工程細(xì)菌
教育背景：
1992.9-1996.6 學(xué)士學(xué)位,， 微生物學(xué),， 四川大學(xué)
2001.9-2006.6 博士學(xué)位， 遺傳學(xué),，中山大學(xué)
工作經(jīng)歷：
2006–2010 博士后研究員,，生物學(xué)系/醫(yī)學(xué)院，美國羅切斯特大學(xué)
2010-2015 博士后研究員,，遺傳學(xué)系,，美國阿爾伯特·愛因斯坦醫(yī)學(xué)院
2015年7月-2015年10月 Associate，遺傳學(xué)系,，美國阿爾伯特·愛因斯坦醫(yī)學(xué)院
2015年10月-2024.12 教授 南京醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院
2019年-2024.12 教授,，生殖醫(yī)學(xué)與子代健康全國重點(diǎn)實(shí)驗(yàn)室，南京醫(yī)科大學(xué)
2024年-至今 教授 南方科技大學(xué)醫(yī)學(xué)院生物化學(xué)系
獲獎(jiǎng)情況及榮譽(yù)：
2024年：南京醫(yī)科大學(xué)十佳研究生導(dǎo)師
2024年：國際基因工程機(jī)器大賽（iGEM）金獎(jiǎng)指導(dǎo)老師
2024年：南京醫(yī)科大學(xué)優(yōu)秀博士論文指導(dǎo)老師
2023年：中國生物物理學(xué)會(huì)優(yōu)秀女科學(xué)家獎(jiǎng)
2022年：江蘇省“333高層次人才培養(yǎng)工程”第二層次人才
2022年：高等學(xué)?？茖W(xué)研究優(yōu)秀成果獎(jiǎng)二等獎(jiǎng)
2022年：國際基因工程機(jī)器大賽（iGEM）金獎(jiǎng)指導(dǎo)老師
2021年：南京醫(yī)科大學(xué)優(yōu)秀碩士論文指導(dǎo)老師
2021年：華夏醫(yī)學(xué)科技獎(jiǎng)一等獎(jiǎng)
2021年：國際基因工程機(jī)器大賽（iGEM）金獎(jiǎng)及最具包容性研究設(shè)計(jì)提名獎(jiǎng)指導(dǎo)老師
2020年：國際基因工程機(jī)器大賽（iGEM）金獎(jiǎng)指導(dǎo)老師
2019年：中國微生物學(xué)會(huì)優(yōu)秀學(xué)術(shù)交流獎(jiǎng)
2017年：江蘇省特聘教授
2016年：江蘇省特聘醫(yī)學(xué)專家
2006年：中山大學(xué)與香港理工大學(xué)聯(lián)合培養(yǎng)博士獎(jiǎng)學(xué)金（2003-2006）
2005年：廣東省南粵優(yōu)秀研究生獎(jiǎng)
2003年：中山大學(xué)優(yōu)秀博士研究生獎(jiǎng)學(xué)金
2002年：中山大學(xué)優(yōu)秀研究生獎(jiǎng)學(xué)金
學(xué)術(shù)任職：
中國醫(yī)藥教育協(xié)會(huì)微生態(tài)與健康副主任委員
中國優(yōu)生科學(xué)協(xié)會(huì)醫(yī)學(xué)遺傳學(xué)專業(yè)委員會(huì)副主任委員
中國神經(jīng)科學(xué)學(xué)會(huì)兒童認(rèn)知和腦功能障礙分會(huì)委員
中國生物物理學(xué)會(huì)腸道菌群常務(wù)委員
代表性論文(*corresponding author)：
1. Zhang Q, Zhao Q, Li T, Lu L, Wang F, Zhang H, Liu Z, Ma H, Zhu Q, Wang J, Zhang X, Pei Y, Liu Q, Xu Y, Qie J, Luan X, Hu Z, Liu X*. Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8+ T cell immunity. Cell Metabolism. 2023;35(6):943-960.e9.
2. Lou M, Cao A, Jin C, Mi K, Xiong X, Zeng Z, Pan X, Qie J, Qiu S, Niu Y, Liang H, Liu Y, Chen L, Liu Z, Zhao Q, Qiu X, Jin Y, Sheng X, Hu Z, Jin G*, Liu J*, Liu X*, Wang Y*. Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder. GUT. 2022; 71(8):1588-1599.
3. Chen K, Luan X, Liu Q, Wang J, Chang X, Snijders AM, Mao J-H, Secombe J, Dan Z, Chen J-H, Wang Z, Dong X, Qiu C, Chang X, Zhang D, Celniker SE, Liu X*. Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance. Cell Host & Microbe. 2019,25:537-552.e8.
4. Mi K, Xu R, Liu X*. Rfw captures species-level metagenomic functions by integrating genome annotation information. Cell Reports Methods. 2024; 4(12):100932.
5. Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X*. Altered gut microbial profile is associated with abnormal metabolism activity of autism spectrum disorder. Gut Microbes. 2020;00:1-22.
6. Liu Z, Zhang Q, Zhang H, Yi Z, Ma H, Wang X, Wang J, Liu Y, Zheng Y, Fang W, Huang P, Liu X. Colorectal cancer microbiome programs DNA methylation of host cells by affecting methyl donor metabolism. Genome Med. 2024;16(1):77.
7. Liu Z, Mi K, Xu ZZ, Zhang Q, Liu X*. PM2RA: A Framework for Detecting and Quantifying Relationship Alterations in Microbial Community. Genomics, proteomics & bioinformatics. 2021; DOI:10.1016/j.gpb.2020.07.005.
8. Mi K, Li Y, Yang Y, Secombe J, Liu X*. DVT: a high-throughput analysis pipeline for locomotion and social behavior in adult Drosophila melanogaster. Cell Biosci. 2023;13(1):187.
9. Shen X, Yang Z, Wang Q, et al., Liu X*, Mo X. Lactobacillus plantarum L168 improves hyperoxia-induced pulmonary inflammation and hypoalveolarization in a rat model of bronchopulmonary dysplasia. Npj biofilms and microbiomes. 2024;10(1):32.
10. Cheng Y, Tan G, Zhu Q, et al., Liu X (Co-corresponding author), Huang H, Wei Y. Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design. Gut Microbes. 2023;15(2):2284247.
11. Xu Y, Wang F, Mi K, et al., Liu X* (Corresponding author). Biglycan regulated colorectal cancer progress by modulating enteric neuron-derived IL-10 and abundance of Bacteroides thetaiotaomicron. iScience. 2023;26(9):107515.
12. Liu Z, Zhang X, Zhang H, Zhang H, Yi Z, Zhang Q, Liu Q, Liu X*. Multi-Omics Analysis Reveals Intratumor Microbes as Immunomodulators in Colorectal Cancer. Microbiol Spectr. 2023;1(2):e0503822.
13. Liu Z, Mao X, Dan Z, et al., Liu X*. Gene variations in autism spectrum disorder are associated with alteration of gut microbiota, metabolites and cytokines. Gut microbes. 2021;13(1):1-16.
14. Mi K, Xu Y, Li Y, Liu X*. QMD: A new method to quantify microbial absolute abundance differences between groups. iMeta. 2023;DOI:10.1002/imt2.78.
15. Xu L, Zhang Q, Dou X, Wang Y, Wang J, Zhou Y, Liu X*, Li J. Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice. J Genet Genomics. 2022;9(11):1042-1052.
16. Wang J, Liu Z, Xu Y, et al., Liu X*. Enterobacterial LPS-inducible LINC00152 is regulated by histone lactylation and promotes cancer cells invasion and migration. Front Cell Infect Microbiol. 2022;12:913815. PMID: 35959377.
17. Zhang R, Zhang Q, Chen Y, Zhao Q, et al., Liu X*, Ni M, Jiang B. Combined treatment with Rg1 and adipose-derived stem cells alleviates DSS-induced colitis in a mouse model. Stem Cell Res Ther. 2022;13(1):272.
18. Wang J, Qie J, Zhu D, et al., Liu X*. The landscape in the gut microbiome of long lived families reveals new insights on longevity and aging-relevant neural and immune function. Gut Microbes. 2022;4(1):2107288.
19. Liu X, Secombe J*. The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif. Cell Rep. 2015;13(10):2219-31.
20. Liu X, Greer C, Secombe J*. KDM5 interacts with Foxo to modulate cellular levels of oxidative stress. PLoS Genet. 2014;10(10):e1004676.
21. Liu C, Lu Q, Xi Q, Xiao S, Du J, Qin R, Wang J, Xu B, Han X, Zhou K, Tao S, Lv H, Jiang Y, Jiang T, Ye K, Jin G, Ma H, Xia Y, Shen H, Liu X*, Lin Y*, Hu Z*. Varying Bifidobacterium species in the maternal-infant gut microbiota correlate with distinct early neurodevelopmental outcomes. J Genet Genomics. 2025;S1673-8527(25)00030-X.
邀請綜述和評論文章：
1. Wang Q, Yang Q, Liu X* The microbiota-gut-brain axis and neurodevelopmental disorders. Protein Cell. 2023 25;14(10):762-775.
2. Lin X, Yu Z, Liu Y, Li C, Hu H, Hu JC, Liu M, Yang Q, Gu P, Li J, Nandakumar KS, Hu G, Zhang Q, Chen X, Ma H, Huang W, Wang G, Wang Y, Huang L, Wu W, Liu NN*, Zhang C*, Liu X*, Zheng *L, Chen P*. Gut-X axis. Imeta. 2025 Feb 26;4(1):e270. doi: 10.1002/imt2.270.
3. Liu X*, The interaction of gut microbiota, genetic variation, and diet in autism spectrum disorder, mLife, 2022, 1(3): 241-244.
4. Zhao Q, and Liu X . 腸道微生物在孤獨(dú)癥中的研究進(jìn)展 [J]. SCIENTIA SINICA Vitae, 《中國科學(xué)》,2023, 605-15.
5. Li Ye, Wang X, and Liu X*. 微生物藥物在神經(jīng)系統(tǒng)疾病中的研究進(jìn)展 [J]. Chinese Bulletin of Life Sciences: 生命科學(xué), 96-306, 2023, 35(3): 296-306.