師資
個人簡介:
陳煒, 1993年畢業(yè)于廈門大學生物化學專業(yè),2002年于四川大學華西醫(yī)學院獲得醫(yī)學遺傳專業(yè)碩士學位,,2002-2006年在德國柏林馬普分子遺傳學研究所師從國際著名人類醫(yī)學遺傳學家H.Hilger Ropers教授攻讀博士,,2006年底獲得博士學位后即被聘為馬普青年科學家小組組長,,2009年被聘為德國馬科斯?德爾布呂克分子醫(yī)學中心醫(yī)學系統(tǒng)生物學研究所基因組中心主任,負責籌建當時德國乃至歐洲最具規(guī)模的基因組中心之一,,2012-2015年作為主要策劃人參與了德國教研部支持的德國最大轉(zhuǎn)化醫(yī)學中心柏林健康研究所的創(chuàng)建,。2015年通過全球招聘成為德國馬科斯?德爾布呂克分子醫(yī)學中心兼柏林夏洛蒂醫(yī)學院終身正(w3)教授。現(xiàn)為南方科技大學生物系講席教授,。
研究領(lǐng)域:
主要從事系統(tǒng)生物學及基因組學研究,研究領(lǐng)域包括基于系統(tǒng)生物學的基因調(diào)控研究,、非編碼RNA的鑒定及功能研究,、人類疾病遺傳學研究、癌癥基因組學研究等幾個方面,。自2007年獨立領(lǐng)導實驗室以來,,作為第一作者或通訊作者發(fā)表論文30篇,總共發(fā)表論文96篇,, 總被引用次數(shù)8181,,H-index達到41 (截至2016年3月29日,基于Google Scholar) ,。2009-2015六年間,,獲得歐盟,德國政府及企業(yè)各類科研項目10余項,,累計經(jīng)費700多萬歐元, 其中牽頭多項德國及歐洲的大型科研項目, 取得多項國際同行高度認可的標志性科研成果,。
工作經(jīng)歷:
2016-至今 南方科技大學生物系 講座教授
2015-2016 德國馬科斯?德爾布呂克國家分子醫(yī)學中心兼柏林夏洛替醫(yī)學院 終身正(w3)教授
2009-2015 德國馬科斯?德爾布呂克國家分子醫(yī)學中心 基因組中心主任 (2011年獲終身研究員位置)
2007-2008 德國馬普分子遺傳學研究所 青年科學家小組組長
學習經(jīng)歷:
2002-2006 德國馬普分子遺傳學研究所 博士
1999-2002 四川大學華西醫(yī)學院 碩士
1989-1993 廈門大學 學士
代表文章:
Hou J, Wang X, McShane E, Zauber H, Sun W, Selbach M, Chen W. Extensive allele-specific translational regulation in hybrid mice. Mol Syst Biol. 2015 Aug 7;11(8):825. doi: 10.15252/msb.156240.
Gao Q, Sun W, Ballegeer M, Libert C, Chen W.Predominant contribution of cis-regulatory divergence in the evolution of mouse alternative splicing. Mol Syst Biol. 2015 Jul 1;11(7):816. doi: 10.15252/msb.20145970.
You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity. Nat Neurosci. 2015 Feb 25. doi: 10.1038/nn.3975. [Epub ahead of print]
Wang, Y., Gogol-D?ring, A., Hu, H., Fr?hler, S., Ma, Y., Jens, M., Maaskola, J., Murakawa, Y., Quedenau, C., Landthaler, M., Kalscheuer, V., Wieczorek, D., Wang, Y., Hu, Y. and Chen, W (2013) Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation. EMBO Mol Med. 2013 doi: 10.1002/emmm.201302663
Sun W, You X, Gogol-D?ring A, He H, Kise Y, Sohn M, Chen T, Klebes A, Schmucker D, Chen W (2013) Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing. EMBO J. 2013 Jun 21. doi: 10.1038/emboj.2013.144. [Epub ahead of print]
Li N, You X, Chen T, Mackowiak SD, Friedl?nder MR, Weigt M, Du H, Gogol-D?ring A, Chang Z, Dieterich C, Hu Y, Chen W (2013) Global profiling of miRNAs and the hairpin precursors: insights into miRNA processing and novel miRNA discovery. Nucleic Acids Res. 2013 Feb 8. [Epub ahead of print]
Mazin P, Xiong J, Liu X, Yan Z, Zhang X, Li M, He L, Somel M, Yuan Y, Phoebe Chen YP, Li N, Hu Y, Fu N, Ning Z, Zeng R, Yang H, Chen W*, Gelfand M*, Khaitovich P*.(2013) Widespread splicing changes in human brain development and aging. Mol Syst Biol. 2013 Jan 22;9:633.
Doering A & Chen W (2012) An overview of the analysis of next generation sequencing data. Methods Mol Biol. 802:249-57
Yan Z, Hu HY, Jiang X, Maierhofer V, Neb E, He L, Hu Y, Hu H, Li N, Chen W*, Khaitovich P* (2011) Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Res. 2011 Aug;39(15):6596-607
Schwanh?usser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J*, Chen W*, Selbach M*. (2011) Global quantification of mammalian gene expression control Nature. 2011 May 19;473(7347):337-42
Adamidi C, Wang Y, Gruen D, Mastrobuoni G, You X, Tolle D, Dodt M, Mackowiak SD, Gogol-Doering A, Oenal P, Rybak A, Ross E, Alvarado AS, Kempa S*, Dieterich C*, Rajewsky N*, Chen W * (2011) De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics. Genome Res 21(7):1193-200
Somel M*, Guo S, Fu N, Yan Z, Hu HY, Xu Y, Yuan Y, Ning Z, Hu Y, Menzel C, Hu H, Lachmann M, Zeng R, Chen W*, Khaitovich P*. (2010) MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Genome Res. 20(9):1207-18
Xu AG, He L, Li Z, Xu Y, Li M, Fu X, Yan Z, Yuan Y, Menzel C, Li N, Somel M, Hu H, Chen W*, P??bo S*, Khaitovich P*. (2010) Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq. PLoS Comput Biol. 6:e1000843.
Hu H, Wrogemann K, Kalscheuer V, Tzschach A, Richard H, Haas SA, Menzel C, Bienek M, Froyen G, Raynaud M, Van Bokhoven H, Chelly J, Ropers H, Chen W. (2010) Mutation screening in 86 known X-linked mental retardation genes by droplet-based multiplex PCR and massive parallel sequencing. The HUGO Journal: Volume 3, Issue 1, Page 41.
Kuss AW, Chen W (2008) MicorRNAs in brain function and disease. Curr Neurol Neurosci Rep. 8(3):190-7.
Chen W, Kalscheu V, Tzschach A, Menzel C, Ullmann R, Schulz M, Erdogan F, Li N, Kijas Z, Arkesteijn G, Pajares IL, Goetz-Sothmann M, Heinrich U, Rost I, Dufke A, Grasshoff U, Glaeser BG, Vingron M, Ropers HH. (2008) Mapping translocation breakpoints by next-generation sequencing. Genome Res. 18(7):1143-9