師資
個(gè)人簡(jiǎn)介
趙健,，南方科技大學(xué)公共衛(wèi)生及應(yīng)急管理學(xué)院助理教授、副研究員、博士生導(dǎo)師,，入選深圳市高層次人才計(jì)劃,。主要研究方向包括：（1）基于大規(guī)模隊(duì)列研究探究生命早期暴露對(duì)全生命周期健康的影響,；（2）分子流行病學(xué)研究中多組學(xué)大數(shù)據(jù)的因果推斷和整合分析（如孟德?tīng)栯S機(jī)化）,；（3）復(fù)雜疾病的藥物新靶點(diǎn)發(fā)現(xiàn),。主持國(guó)家自然科學(xué)基金-面上項(xiàng)目,、國(guó)家自然科學(xué)基金-國(guó)際（地區(qū)）合作研究與交流項(xiàng)目,、深圳市醫(yī)科院醫(yī)學(xué)專項(xiàng)基金項(xiàng)目、中英國(guó)際合作項(xiàng)目（英方PI）和上海交通大學(xué)卓越公共衛(wèi)生人才培養(yǎng)等項(xiàng)目,，并作為研究骨干參與歐洲研究委員會(huì)（ERC）,、英國(guó)國(guó)立衛(wèi)生研究院（NIHR）、David Telling Charitable Trust資助項(xiàng)目和上海市科委國(guó)際科技合作項(xiàng)目,。
截至目前,，共發(fā)表學(xué)術(shù)論文50余篇，其中包括以第一或者通訊作者身份發(fā)表在Journal of Hepatology, Lancet-eBioMedicine, BMC Medicine, J Clin Endoc Metab, Computer Methods and Programs in Biomedicine, Human Reproduction, Liver International等領(lǐng)域內(nèi)權(quán)威期刊,，并擔(dān)任BMC Medicine, Scientific Reports編委及包括Journal of Hepatology,、Diabetes Care、International Journal of Epidemiology,、Fertility and Sterility,、Diabetologia、Computers in Biology and Medicine等多個(gè)領(lǐng)域內(nèi)權(quán)威SCI學(xué)術(shù)期刊的審稿人和review editor,。
課題組長(zhǎng)期招收碩士生,、博士生（包括直博生）、博士后,、研究助理（RA）和訪問(wèn)學(xué)生,。申請(qǐng)者請(qǐng)將CV和Personal Statement發(fā)郵件至[email protected].
研究方向
1. 基于大規(guī)模隊(duì)列研究探究生命早期暴露對(duì)全生命周期健康的影響
2. 分子流行病學(xué)研究中多組學(xué)大數(shù)據(jù)的因果推斷和整合分析（多基因風(fēng)險(xiǎn)評(píng)分、多組學(xué)孟德?tīng)栯S機(jī)化分析等）
3. 復(fù)雜疾病的藥物新靶點(diǎn)發(fā)現(xiàn)
教育經(jīng)歷
2014-2019 澳大利亞科廷大學(xué),，博士
2011-2014 四川大學(xué),，碩士
2006-2011 安徽醫(yī)科大學(xué)，學(xué)士
工作經(jīng)歷
2023/12–至今,，南方科技大學(xué)公共衛(wèi)生及應(yīng)急管理學(xué)院,，助理教授、副研究員,、博士生導(dǎo)師
2021-2023,，上海交通大學(xué)醫(yī)學(xué)院附屬新華醫(yī)院/公共衛(wèi)生學(xué)院（兼聘），青年P(guān)I
2018-2020,，英國(guó)布里斯托大學(xué)MRC-Integrative Epidemiology Unit,，Senior Research Associate
榮譽(yù)及獎(jiǎng)項(xiàng)
布里斯托大學(xué)榮譽(yù)研究員
Skills Training and Development Award（UK - BBSRC）
HOPE Fellow（日本學(xué)術(shù)振興會(huì)）
近期科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金-面上項(xiàng)目：GLS2調(diào)控的谷氨酰胺代謝影響兒童非酒精性脂肪肝發(fā)病風(fēng)險(xiǎn)的出生隊(duì)列及機(jī)制研究。2024–2027（主持）
2. 國(guó)家自然科學(xué)基金-國(guó)際（地區(qū)）合作研究與交流項(xiàng)目：2025（主持）
3. 深圳市醫(yī)學(xué)研究專項(xiàng)基金-臨床醫(yī)學(xué)專項(xiàng)：牙周炎影響子癇前期高風(fēng)險(xiǎn)孕婦母胎結(jié)局的機(jī)制及干預(yù)策略研究,。2025-2028（共同主持,，Co-PI）
4. 深圳市醫(yī)學(xué)研究專項(xiàng)基金-人才提升青年項(xiàng)目：孟德?tīng)栯S機(jī)化分析中時(shí)依暴露的因果推斷方法及應(yīng)用研究。2025-2027（主持）
5. 國(guó)際科技合作項(xiàng)目：Children and adolescents' mental health and association with sleep pattern during the COVID-19 pandemic. 2020-2021（主持）
6. 上海市“科技創(chuàng)新行動(dòng)計(jì)劃”國(guó)際科技合作項(xiàng)目：新型全氟化合物影響妊娠糖尿病的隊(duì)列研究和機(jī)制探討。2021-2024（參與）
代表性論文（#共同一作,，*通訊作者）
1. Zhao J*, Zeng J, Zhu C, Li X, Liu D, Zhang J, Li F, Targher G, Fan JG*. Genetically predicted plasma levels of amino acids and metabolic dysfunction-associated fatty liver disease risk: a Mendelian randomization study. BMC Medicine. 2023 Dec;21(1):1-2. (JCR Q1, IF = 11.15)
2. Zhao J*, Stewart ID, Baird D, Mason D, Wright J, Zheng J, Gaunt TR, Evans DM, Freathy RM, Langenberg C, Warrington NM. Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study. EBioMedicine. 2023 Feb 1;88. (JCR Q1, IF = 11.21)
3. Liu D, Gao X, Pan XF, Zhou T, Zhu C, Li F, Fan JG, Targher G, Zhao J*. The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome. BMC Medicine. 2023 Feb 20;21(1):62. (JCR Q1, IF = 11.15)
4. Liu D, Zhang Q, Bai P, Zhao J*. Assessing causal relationships between COVID-19 and non-alcoholic fatty liver disease, Journal of Hepatology, 2022 Mar 1;76(3):740-2. (JCR Q1, IF=30.08)
5. Zeng J, Jin Q, Yang J, Yang RX, Zhang RN, Zhao J*, Fan JG*. Prevalence and incidence of MAFLD and associated anthropometric parameters among prepubertal children of the Shanghai Birth Cohort. Hepatology International. 2023 Sep 20:1-3. (JCR Q1, IF = 6.6)
6. Yan R, Liu L, Tzoulaki I, Fan JG, Targher G, Yuan Z*, Zhao J*. Genetic Evidence for GLP‐1 and GIP Receptors as Targets for Treatment and Prevention of MASLD/MASH. Liver International. 2024. (JCR Q1, IF = 6.0)
7. Li Z, Li X, Fang S, Liu D, Li F, Zhu C*, Zhao J*. Lifelong impacts of puberty timing on human plasma metabolic profiles: A metabolome‐wide Mendelian randomization study. Diabetes, Obesity and Metabolism. 2024. (JCR Q1, IF = 5.4)
8. Peng Q, Qiu W, Li Z, Zhao J*, Zhu C*. Fetal genetically determined birth weight plays a causal role in earlier puberty timing: evidence from human genetic studies. Human Reproduction. 2024 Apr 1;39(4):792-800. (JCR Q1, IF = 6.1)
9. Sun J, Zhou J, Gong Y, Pang C, Ma Y, Zhao J, Yu Z, Zhang Y. Bayesian network-based Mendelian randomization for variant prioritization and phenotypic causal inference. Human Genetics. 2024 Feb 21:1-14. (JCR Q1, IF = 3.8)
10. Gan Y, Lu D, Yan C*, Zhang J*, Zhao J*. Maternal polycystic ovary syndrome and offspring birth weight: a Mendelian randomization study, The Journal of Clinical Endocrinology & Metabolism, 2021 Nov 24. (JCR Q1, IF= 6.13)
11. Zhao J, Xu J, He Y, Xiang M, Children and adolescents’ sleep patterns and their associations with mental health during the COVID-19 pandemic in Shanghai, China, Journal of Affective Disorders, 2022 Mar 15; 301: 337-344. (JCR Q1, IF= 6.53)
12. Zhao J, Zhao Y, Xiang L, Khanal V, Binns CW, Lee AH. A two-part mixed-effects model for analyzing clustered time-to-event data with clumping at zero. Computer Methods and Programs in Biomedicine. 2020 Apr 1;187:105196. (JCR Q1, IF=7.64)
13. Zeng X, Chen T, Cui Y, Zhao J, Chen Q, Yu Z, Zhang Y, Han L, Chen Y, Zhang J. In utero exposure to perfluoroalkyl substances and early childhood BMI trajectories: A mediation analysis with neonatal metabolic profiles. Science of The Total Environment. 2023 Apr 1;867:161504. (JCR Q1, IF = 10.75)
14. Ye J, Chen Y, Yang H, Chen Q, Huang Y, Zhao J, Tu L, Liu M, Zhang J. A nationwide cross-sectional survey of episiotomy practice in China. The Lancet Regional Health–Western Pacific. 2022 Feb 1;19. (JCR Q1, IF = 7.6)