師資
南方科技大學醫(yī)學院/前沿生物技術研究院教授,。2016-2022年曾任職中國科學院分子植物科學卓越創(chuàng)新中心研究員,、博士生導師。2009年北京師范大學獲得學士學位,2014年美國普渡大學獲得博士學位,師從朱健康教授,。入選第十四批海外引才項目青年組、上海市青年拔尖人才,、中國科學院BR計劃,、上?？萍记嗄?5人引領計劃入選者,、中國科學院青年英才培育計劃,、鵬城孔雀計劃,2022年獲得教育部自然科學二等獎、2023年獲得山東省科學技術獎一等獎,。主要從事植物中DNA甲基化的分子機制及果實發(fā)育中生物學功能的研究以及植物基因編輯系統(tǒng)的開發(fā)工作,系統(tǒng)闡述了DNA甲基化動態(tài)形成的分子機制,及其在果實成熟中的生物學功能。在Molecular Cell,、PNAS,、Genome Biology、Nature Plants,、Developmental Cell等國際權威期刊發(fā)表SCI論文53篇,通訊/共同通訊作者28篇,。主持國家重點研發(fā)等國家級項目6項。擔任國際期刊Horticulture Research副主編,、JIPB副主編,、Plant Direct編委、aBIOTECH編委,、植物生理學報雜志編委,。
教學和科研成果
1. 系統(tǒng)闡述了DNA甲基化動態(tài)形成的分子機制：發(fā)現(xiàn)了真核生物中第一個調控DNA去甲基化的蛋白復合體(Molecular Cell, 2015); 發(fā)現(xiàn)了首個激活型組蛋白修飾參與調控DNA甲基化通路(Nature Communications, 2021；Plant Journal, 2021); 首次闡述了真核生物中DNA甲基化及去甲基化通路在全基因組的拮抗作用(Nature Plants, 2016),。在遺傳學研究中,植物研究體系一直起到了至關重要的作用,。很多重要保守的遺傳機制都是首先在植物中發(fā)現(xiàn)的,比如孟德爾定律。在表觀遺傳研究中,DNA甲基化相關的一系列成果都是首先在植物中被發(fā)現(xiàn),。其中,本課題組的研究對于廣泛理解在真核生物中DNA甲基化的動態(tài)平衡機制有引領性的作用,。
2. 揭示了DNA甲基化在果實成熟中的重要作用：首次揭示了DNA去甲基化酶在番茄成熟中的必要性(PNAS, 2017; New Phytologist, 2022);率先發(fā)現(xiàn)了DNA甲基化在草莓和柑橘等果實中的重要作用,及其動態(tài)變化的獨特分子機制(Genome Biology, 2018; PNAS, 2019)。果實成熟是生物衰老相關的重要過程,。表觀遺傳調控果實成熟是世界范圍內新興且有重要意義的研究領域,。近年來,表觀遺傳多樣性被認為是提供育種中遺傳多樣性的重要途徑之一。本課題組的研究為表觀遺傳多樣性在作物育種中的應用提供了重要理論基礎,也為研究癌癥發(fā)生和人體衰老中DNA甲基化的動態(tài)變化提供了新思路,。
代表性論文：
1. Huan Huang; Ruie Liu; Qingfeng Niu; Kai Tang; Bo Zhang; Heng Zhang; Kunsong Chen; JianKang Zhu; Zhaobo Lang; Global increase in DNA methylation during orange fruit development and ripening, Proceedings of the National Academy of Sciences, 2019, 116(4): 1430-1436 (共同通訊作者)
2. Yunduan Li; Yanna Shi; Yichen Li; Jiao Lu; Yunfan Sun; Yuanyuan Zhang; Wenbo Chen; Xiaofang Yang; Donald Grierson; Zhaobo Lang; Guihua Jiang; Kunsong Chen; DNA methylation mediated by RdDM pathway and demethylation affects furanone accumulation through regulation of QUINONE OXIDOREDUCTASE in strawberry, Horticulture Research, 2023, 10(8) (共同通訊作者)
3. Chao Gu; Mao-Song Pei; Zhi-Hua Guo; Lei Wu; Kai-Jie Qi; Xue-Ping Wang; Hong Liu; Zhongchi Liu; Zhaobo Lang; Shaoling Zhang; Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism, Genome Biology, 2024, 25(70)(共同通訊作者)
4. Ying Gao; Yujing Lin; Min Xu; Hanxiao Bian; Chi Zhang; Jingyu Wang; Hanqing Wang; Yaping Xu; Qingfeng Niu; Jinhua Zuo; Da-Qi Fu; Yu Pan; Kunsong Chen; Harry Klee; Zhaobo Lang; Bo Zhang; The role and interaction between transcription factor NAC-NOR and DNA demethylase SlDML2 in the biosynthesis of tomato fruit flavor volatiles, New Phytologist, 2022, 235(5): 1913- 1926(共同通訊作者 )
5. Qingfeng Niu; Siqun Wu; Hongtao Xie; Qi Wu; Ping Liu; Yaping Xu; Zhaobo Lang; Efficient A·T to G·C Base Conversions in Dicots Using Adenine Base Editors Expressed under the Tomato EF1α Promoter, Plant Biotechnology Journal, 2023, 0(0)(唯一通訊作者)
6. Yuyun Zhang; Zijuan Li; Jinyi Liu; Yu’e Zhang; Luhuan Ye; Yuan Peng; Haoyu Wang; HuishanDiao; Yu Ma; Meiyue Wang; Yilin Xie; Tengfei Tang; Yili Zhuang; Wan Teng; Yiping Tong; Wenli Zhang; Zhaobo Lang; Yongbiao Xue; Yijing Zhang; Transposable elements orchestrate subgenome convergent and-divergent transcription in common wheat, Nature Communications, 2022,13(1)(共同通訊作者 )
7. Pei Huang; Huan Huang; Xueqiang Lin; Pan Liu; Lun Zhao; Wen-Feng Nie; Jian-Kang Zhu; Zhaobo Lang; MSI4/FVE is required for accumulation of 24-nt siRNAs and DNA methylation at a subset of target regions of RNA-directed DNA methylation, the Plant Journal, 2021, 108: 347-357(唯一通訊作者 )
8. Qingfeng Niu; Zhe Song; Kai Tang; Lixian Chen; Lisi Wang; Ting Ban; Zhongxin Guo; Chanhong Kim; Heng Zhang; Cheng-Guo Duan; Huiming Zhang; Jian-Kang Zhu; Jiamu Du; Zhaobo Lang; A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation, Nature Communications, 2021, 12(1): 3367-3380 (唯一通訊作者)
9. Yuyun Zhang; Zijuan Li; Yu'e Zhang; Kande Lin; Yuan Peng; Luhuan Ye; Yili Zhuang; Meiyue Wang; Yilin Xie; Jingyu Guo; Wan Teng; Yiping Tong; Wenli Zhang; Yongbiao Xue; Zhaobo Lang; Yijing Zhang; Evolutionary rewiring of the wheat transcriptional regulatory network by lineagespecific transposable elements, Genome Research, 2021, 31(共同通訊作者)
10. Qingfeng Niu; Siqun Wu; Xiaoxuan Yang; Ping Liu; Yaping Xu; Zhaobo Lang; Expanding the Scope of CRISPR/Cas9-Mediated Genome Editing in plants using an xCas9 and Cas9-NG hybrid, Journal of Integrative Plant Biology, 2020, 62(4): 398-402 (唯一通訊作者)
11. Dengguo Tang; Philippe Gallusci; Zhaobo Lang; Fruit development and epigenetic modifications, New Phytologist, 2020, 228: 839-844 (唯一通訊作者 )
12. Jingfei Cheng; Qingfeng Niu; Bo Zhang; Kunsong Chen; Ruihua Yang; Jian-Kang Zhu; Yijing Zhang; Zhaobo Lang; Downregulation of RdDM during strawberry fruit ripening, Genome Biology, 2018, 19(1): 212-226 (共同通訊作者 )
13. Zhaobo Lang; Yihai Wang; Kai Tang; Dengguo Tang; Tatsiana Datsenka; Jingfei Cheng; Yijing Zhang; Avtar K. Handa; Jian-Kang Zhu; Critical roles of DNA demethylation in the activation of ripening-induced genes and inhibition of ripening-repressed genes in tomato fruit, Proceedings of the National Academy of Sciences, 2017, 114(22): 4511-4519 ( 唯一第一作者, 共同通訊作者 )
14. Kai Tang; Zhaobo Lang; Heng Zhang; Jian-Kang Zhu; The DNA demethylase ROS1 targets genomic regions with distinct chromatin modifications, Nature Plants, 2016, 2(11): 16169- 16169 (共同第一作者, 唯一通訊作者)
15. Zhaobo Lang; Mingguang Lei; Xingang Wang; Kai Tang; Daisuke Miki; Huiming Zhang; Satendra K. Mangrauthia; Wenshan Liu; Wenfeng Nie; Guojie Ma; Jun Yan; Cheng-Guo Duan; Chuan-Chih Hsu; Chunlei Wang; W. Andy Tao; Zhizhong Gong; Jian-Kang Zhu; The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing, Molecular Cell, 2015, 57(6): 971-983(共同第一作者)