師資
個人簡介:
姚青,,香港大學醫(yī)學院博士,在美國密歇根大學醫(yī)學院接受博士后訓練。從博士期間起開始專注于骨骼發(fā)育與疾病的研究,感興趣的領(lǐng)域包括軟骨發(fā)育及軟骨細胞代謝,骨骼發(fā)育中的缺氧機制和缺氧誘導因子HIFs的功能及作用機理,,骨性關(guān)節(jié)炎中軟骨細胞的代謝機制,軟骨細胞中內(nèi)質(zhì)網(wǎng)應(yīng)激信號通路與缺氧信號通路的相互作用等。近五年內(nèi),,在Developmental Cell, Bone Research 等著名SCI雜志發(fā)表研究論文數(shù)篇。曾受邀參加ASBMR (American Society for Bone and Mineral Research),,The Frederick J. Fisher Pediatric Orthopaedic Lectureship等國際及專業(yè)會議做學術(shù)報告,,并獲得ASBMR 頒發(fā)的2017年青年研究學者榮譽。
教育背景:
2010.09-2015.02,,香港大學,,醫(yī)學院,,博士
2006.09-2009.06,中山大學,,生命科學學院,,碩士
2002.09-2006.06,華中師范大學,,生命科學學院,,學士
外國語學院,學士
工作經(jīng)歷:
2020.05-至今,, 南方科技大學,,醫(yī)學院,助理研究教授
2015.05-2017.10,, 美國密歇根大學,,醫(yī)學院,博士后研究員
2009.08-2010.08,, 中山大學,,生物工程中心,研究助理
獲獎情況及榮譽:
ASBMR Young Investigator Award, 2015(美國骨與礦物研究協(xié)會,,青年研究學者獎)
獲得研究基金:
10/2016-10/2017 美國密歇根大學醫(yī)學院,,骨科專項研究基金
09/2020-08/2022 深圳市穩(wěn)定支持計劃面上項目基金 金額:50萬元 人民幣
題目:創(chuàng)傷后骨性關(guān)節(jié)炎發(fā)生早期關(guān)節(jié)軟骨細胞代謝程序的改變
01/2022-12/2025 國家自然科學基金面上項目基金 金額:53萬元 人民幣
題目:線粒體轉(zhuǎn)錄因子A(TFAM)調(diào)節(jié)軟骨細胞能量代謝終極分化的作用和機制
學術(shù)任職:
6/2016 – 至今 Medicine 審稿人,雜志學術(shù)編輯
6/2018 – 至今 Aging 審稿人
發(fā)表論文:
1. Yao Q., Parvez Khan M, Schipani E. “In vivo survival strategies for cellular adaptation to hypoxia: HIF1α-dependent suppression of mitochondrial oxygen consumption and decrease of intracellular hypoxia are critical for survival of hypoxic chondrocytes.” Bone, 2020, 140(115572)
2. Yao, Q., Parvez Khan M, Merceron C, LaGory E, Tata Z, Mangiavini L, Hu J, Vemulapalli K, Chandel NS, Giaccia AJ, Schipani E. “Suppressing mitochondrial respiration is critical for hypoxia tolerance in the fetal growth plate.” (2019) Developmental Cell,49:748-763 (Preview in the same issue of Developmental Cell; featured in the Editor’s Choice of Science Signaling 2019;12)
3. Merceron, C., Ranganathan, K., Wang, E., Tata, Z., Makkapati, S., Khan, M. P., Mangiavini, L., Yao, A. Q., Castellini, L., Levi, B., Giaccia, A. J., Schipani, E. “Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual.” (2019) Bone research, 7:7
4. Kudelko M., Chan C.W., Sharma R., Yao Q., Lau, E., Chu, I.K., Cheah, K.S.E., Tanner, J.A. and Chan, D. "Label-Free Quantitative Proteomics Reveals Survival Mechanisms developed by hypertrophic chondrocytes under ER stress." (2016) J.Proteome Res. 15(1):86-99
5. Pineault KM., Swinehart IT.,Garthus KN., Ho E., Yao Q., Schipani E., Kozloff KM.,Wellik DM. "Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation." (2015) Biol Open, 4(11),1538-1548
6. Zhang, Q. Q., H. Xu, M. B. Huang, L. M. Ma, Q. J. Huang, Yao, Q., H. Zhou, and L. H. Qu. "Microrna-195 Plays a Tumor-Suppressor Role in Human Glioblastoma Cells by Targeting Signaling Pathways Involved in Cellular Proliferation and Invasion." Neuro Oncol 14, no. 3 (2012): 278-87.
7. Yao, Q., H. Xu, Q. Q. Zhang, H. Zhou, and L. H. Qu. "Microrna-21 Promotes Cell Proliferation and Down-Regulates the Expression of Programmed Cell Death 4 (Pdcd4) in Hela Cervical Carcinoma Cells." Biochem Biophys Res Commun 388, no. 3 (2009): 539-42.
8. Zhang R, Yao Q, Peng JX, Hong HZ, (2006) “The Structure, Function and Evolution of Baculoviral Inhibitor of Apoptosis Gene.” Microbiology China. 0253-2654 (2006) 01-0128-05
9. Li JJ, Yao Q, Yang DY, Yu ZH, Chen XW, (2005) “Cloning and Expression of Ubiquitin Gene of Helicoverpa armigera Single-nucleocapsid Nucleopolyhedrovirus and its Antiserum Preparation.” Virologica Sinica. 20 (3): 298-302