師資
徐明華,，浙江岱山人,。1999年7月博士畢業(yè)于中國科學(xué)院上海有機(jī)化學(xué)研究所，先后在美國弗吉尼亞大學(xué)和喬治敦大學(xué)醫(yī)學(xué)研究中心從事博士后工作研究,，2003年8月加入中國科學(xué)院上海有機(jī)化學(xué)研究所,，2005年入選中國科學(xué)院項(xiàng)目,，7月起任中國科學(xué)院上海藥物研究所研究員,、課題組長、博士生導(dǎo)師,，新藥研究國家重點(diǎn)實(shí)驗(yàn)室研究員,。2018年受邀加入南方科技大學(xué)，現(xiàn)任化學(xué)系和深圳格拉布斯研究院雙聘教授,。
主要從事有機(jī)不對稱合成及手性藥物方面的研究，研究方向包括：新型手性配體/催化劑的設(shè)計(jì)及不對稱反應(yīng)研究,；生物活性分子的高效合成和小分子藥物發(fā)現(xiàn),；基于疾病診斷的小分子熒光探針研究。
在國內(nèi)外核心學(xué)術(shù)期刊上發(fā)表論文130余篇,，多個(gè)工作受到國際國內(nèi)同行的關(guān)注和好評(píng),，被美國化學(xué)會(huì)ACS “Heart Cut” (2次)，“Noteworthy Chemistry” (2次),，德國化學(xué)評(píng)論期刊Synfacts (34次),，英國Speciality Chemicals Magazine專欄，JACS Spotlights,，Organic Chemistry Portal,，X-MOL等選為研究亮點(diǎn)報(bào)道；12篇論文被選為期刊封面(其中1篇J. Am. Chem. Soc.封面),；申請國內(nèi)外專利24項(xiàng),，授權(quán)17項(xiàng)（美國專利2項(xiàng)）。應(yīng)邀在國際性學(xué)術(shù)會(huì)議,、海外知名大學(xué)作學(xué)術(shù)邀請報(bào)告100多次,。
曾獲中國化學(xué)會(huì)青年化學(xué)獎(jiǎng)(2005)，首屆藥明康德生命化學(xué)研究獎(jiǎng)(2007),，中國科學(xué)院朱李月華優(yōu)秀教師獎(jiǎng)(2012),，中科院優(yōu)秀研究生指導(dǎo)教師(2013)，國家杰出青年科學(xué)基金(2013),，上海市優(yōu)秀學(xué)術(shù)帶頭人(2014),，中國科學(xué)院特聘骨干研究員(2015)，深圳市國家級(jí)領(lǐng)軍人才(2018),，廣東省“珠江人才計(jì)劃”領(lǐng)軍人才(2019),，前沿有機(jī)化學(xué)Asian Core Program Lectureship Award（日本3次、韓國,、新加坡,、泰國,、臺(tái)灣），以及法國斯特拉斯堡大學(xué)邀請教授,、日本九州大學(xué)“Global 30”計(jì)劃“Part-time Lecturer”,、臺(tái)灣國科會(huì)化學(xué)促進(jìn)中心訪問教授、日本北海道大學(xué)Hokkaido Summer Institute邀請教授等榮譽(yù),。2014年獲上海市自然科學(xué)一等獎(jiǎng),，2016年獲國家自然科學(xué)二等獎(jiǎng)。
榮譽(yù)及獎(jiǎng)勵(lì)
2018 深圳市國家級(jí)領(lǐng)軍人才
2018 日本北海道大學(xué)Hokkaido Summer Institute特別邀請教授
2018 《科學(xué)通報(bào)》編委
2018 Elsevier開放期刊《Heliyon》編委
2016 國家自然科學(xué)二等獎(jiǎng)（第二完成人）
2016 PERCH-CIC Congress IX: 2016 International Congress for Innovation in Chemistry, June 26-29, Pattaya, Thailand (Plenary Lecture)
2016 客座編輯Tetrahedron Symposia-in-Print for “Chiral Sulfur Ligands/Catalysts in Asymmetric Catalysis”
2015 中國科學(xué)院特聘研究員（骨干）
2015 上海市研究生優(yōu)秀學(xué)位論文指導(dǎo)教師
2014 上海市自然科學(xué)一等獎(jiǎng)（第二完成人）
2014 亞洲核心計(jì)劃講座獎(jiǎng)JSPS Asian Core Program Lectureship Award (Japan)
2014 上海市優(yōu)秀學(xué)術(shù)帶頭人
2014 上海市研究生優(yōu)秀學(xué)位論文指導(dǎo)教師
2013 國家自然科學(xué)杰出青年基金
2013 中國科學(xué)院優(yōu)秀研究生指導(dǎo)教師
2013 臺(tái)灣國科會(huì)化學(xué)促進(jìn)中心訪問教授
2013 日本九州大學(xué)(Kyushu University) 客座教授 (Part-Time Lecturer)
2012 BOSS XIII (the 13th Belgian Organic Synthesis Symposium), July 15-20, 2012, Leuven, Belgium (Plenary Lecture)
2012 中國科學(xué)院朱李月華優(yōu)秀教師獎(jiǎng)
2011 法國斯特拉斯堡大學(xué)(Univ. of Strasbourg)邀請教授(Invited Professor)
2010 亞洲核心計(jì)劃講座獎(jiǎng)Asia Core Program Lectureship Award (Korea)
2009 亞洲核心計(jì)劃講座獎(jiǎng)Asia Core Program Lectureship Awards (Taiwan and Thailand)
2008 亞洲核心計(jì)劃講座獎(jiǎng)Asian Core Program Lectureship Award (Singapore)
2008 上海市青年科技啟明星后
2008 中科院上海分院杰出青年科技創(chuàng)新人才提名獎(jiǎng)
2007 亞洲核心計(jì)劃講座獎(jiǎng)JSPS Asian Core Program Lectureship Award (Japan)
2007 首屆藥明康德生命化學(xué)研究獎(jiǎng)
2006 亞洲核心計(jì)劃講座獎(jiǎng)JAPS Asian Core Program Lectureship Award (Japan)
2005 中國化學(xué)會(huì)青年化學(xué)獎(jiǎng)
2005 中國科學(xué)院
2005 上海市青年科技啟明星
研究方向
1,、不對稱合成與手性藥物研究
2,、新型手性配體/催化劑的設(shè)計(jì)、合成以及在不對稱反應(yīng)中的應(yīng)用研究
3,、具重要生理活性的有機(jī)分子或藥物分子的高效合成以及反應(yīng)方法學(xué)研究
4,、小分子藥物研究和發(fā)現(xiàn)
代表性論文
Yi Li, Bo Liu, and Ming-Hua Xu*, Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Practical Synthesis of Multifunctional Chiral α,α-Disubstituted Allylic Amine Derivatives”, Org. Lett. 2018, 20, 2306-2310. (Highlighted by Synfacts, 2018, 14(6), 0596)
Chun-Yan Wu, Yu-Fang Zhang, and Ming-Hua Xu*, “Ligand-Controlled Rhodium-Catalyzed Site-Selective Asymmetric Addition of Arylboronic Acids to α,b-Unsaturated Cyclic N-Sulfonyl Ketimines”, Org. Lett. 2018, 20, 1789-1793. (Highlighted by Synfacts, 2018, 14(6), 0597)
Zong-Fen Zhang, Dong-Xing Zhu, Wen-Wen Chen, Bin Xu* and Ming-Hua Xu*, “Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis”, Org. Lett. 2017, 19, 2726-2729. (Highlighted by Synfacts, 2017, 13(8), 0838, Abstracted by Organic Chemistry Portal)
Tao Jiang, Wen-Wen Chen, and Ming-Hua Xu*, “Highly Enantioselective Arylation of N,N-Dimethylsulfamoyl-Protected Aldimines Using Simple Sulfur–Olefin Ligands: Access to Solifenacin and (S)-(+)-Cryptostyline II”, Org. Lett. 2017, 19, 2138-2141. (Highlighted by Synfacts, 2017, 13(7), 0720)
Chun-Yan Wu, Yue-Na Yu, and Ming-Hua Xu*, “Construction of Chiral Tricyclic Indoles through a Rhodium-Catalyzed Asymmetric Arylation Protocol”, Org. Lett. 2017, 19, 384-387. (Highlighted by Synfacts, 2017, 13(3), 0298)
Wen-Wen Chen, and Ming-Hua Xu*, “Rhodium Complex Catalysis in Asymmetric Synthesis of Heterocycles”, Org. Biomol. Chem. 2017, 15, 1029-1050. (Invited Review; Cover Article)
Xu Zhang, Bin Xu,* and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Arylation of N- and O-Containing Cyclic Aldimines: Facile and Efficient Access to Highly Optically Active 3,4-Dihydrobenzo[1,4]oxazin-2-ones and Dihydroquinoxalinones”, Org. Chem. Front. 2016, 3, 944-948. (Highlighted by Organic Chemistry Portal; Abstracted by ChemInform, 2016, 10.1002/chin.201648022)
Yu-Fang Zhang, Diao Chen, Wen-Wen Chen, and Ming-Hua Xu*, “Construction of Cyclic Sulfamidates Bearing Two gem-Diaryl Stereocenters through a Rhodium-Catalyzed Stepwise Asymmetric Arylation Protocol”, Org. Lett. 2016, 18, 2726-2729. (Highlighted by Synfacts, 2016, 12(8), 0837; Abstracted by ChemInform, 2016, 10.1002/chin.201644021)
Diao Chen, Dong-Xing Zhu, and Ming-Hua Xu*, “Rhodium(I)-Catalyzed Highly Enantioselective Insertion of Carbenoid into Si-H: Efficient Access to Functional Chiral Silanes”, J. Am. Chem. Soc. 2016, 138, 1498-1501. (Highlighted by Synfacts, 2016, 12(4), 0385; also highlighted atJACS journal homepage; Abstracted by ChemInform, 2016, 10.1002/chin.201630222; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)
Yi Li, Yue-Na Yu, and Ming-Hua Xu*, “Simple Open-Chain Phosphite-Olefin as Novel Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl α-Amino Acid Derivatives”, ACS Catalysis, 2016, 6, 661-665. (Highlighted at ACS Catalysisjournal homepage)
Diao Chen, Xu Zhang, Wei-Yi Qi, Bin Xu and Ming-Hua Xu*, “Rhodium(I)-Catalyzed Asymmetric Carbene Insertion into B-H Bonds Using Unprecedented C1-Symmetric Chiral Diene Ligand: Highly Enantioselective Access to Functionalized Organoboranes”, J. Am. Chem. Soc. 2015,137, 5268-5271. (Cover Article, Featured in JACS Spotlights; Highlighted by Synfacts, 2015, 11(5), 0502; Abstracted by ChemInform, 2015, 10.1002/chin.201538189)
Tao Jiang, Zheng Wang and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Arylation of Cyclic N-Sulfonyl Aryl Alkyl Ketimines：Efficient Access to Highly Enantioenriched α-Tertiary Amines”, Org. Lett. 2015, 17, 528-531. (Highlighted by Synfacts, 2015, 11(4), 0367; Abstracted byChemInform, 2015, 10.1002/chin.201525171)
Yi Li, and Ming-Hua Xu*, “Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin”, Org. Lett. 2014, 16, 2712- 2715. (Highlighted by Synfacts, 2014, 10(7), 0680; Abstracted by ChemInform, 2014, 10.1002/chin.201443089)
Yi Li, and Ming-Hua Xu*, “Simple Sulfur-Olefins as New Promising Chiral Ligands for Asymmetric Catalysis”, Chem. Commun. 2014, 50, 3771- 3782. (Invited Feature Article; Cover Article; Abstracted by ChemInform, 2014, 45, 22-025)
Yi Li, Dong-Xing Zhu, and Ming-Hua Xu*, “A New Versatile Approach to Enantioenriched 3-Hydroxyoxindoles, 1,3-Dihydroisobenzofuran and 3-Isochromanone Derivatives by Rhodium-Catalyzed Asymmetric Arylation/Cyclization Sequence”, Chem. Commun. 2013, 49, 11659-11661. (Highlighted by Synfacts, 2014, 10(3), 0285; selected as an article of ChemComm Editor’s Choice; Abstracted by ChemInform, 2014, 45, 17-025)
Hui Wang, Tao Jiang, and Ming-Hua Xu*, “Simple Branched Sulfur-Olefins as Chiral Ligands for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Highly Enantioselective Construction of Tetrasubstituted Carbon Stereocenters”, J. Am. Chem. Soc. 2013, 135, 971-974. (Highlighted by Synfacts, 2013, 9(4), 0416; Abstracted by ChemInform, 2013, 44, 26-123; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)
Shen-Shuang Jin, Hui Wang, Ting-Shun Zhu, and Ming-Hua Xu*, “Design of N-Cinnamyl Sulfinamides as New Sulfur-Containing Olefin Ligands for Asymmetric Catalysis: Achieving Structural Simplicity with a Categorical Linear Framework”, Org. Biomol. Chem. 2012, 10, 1764-1768. (Cover Article, highlighted on the OBC blog and also by Synfacts, 2012, 8(6), 0651; Abstracted by ChemInform, 2012, 43, 29-095; Featured in the top 10% of the most highly cited OBC articles published in the latest Impact Factor window (2011-2012))
Ting-Shun Zhu, Shen-Shuang Jin, and Ming-Hua Xu*, “Rhodium-Catalyzed Highly Enantioselective 1,2-Addition of Arylboronic Acids to α-Ketoesters and α-Diketones Using Simple Chiral Sulfur-Olefin Ligands”, Angew. Chem. Int. Ed. 2012, 51, 780-783. (Highlighted by Synfacts,2012, 8(4), 0422; Abstracted by ChemInform, 2012, 43, 23-023).
Shen-Shuang Jin, Hui Wang, and Ming-Hua Xu*, “Design of N-Sulfinyl Homoallylic Amines as Novel Sulfinamide-Olefin Hybrid Ligands for Asymmetric Catalysis: Application in Rh-Catalyzed Enantioselective 1,4-Additions”, Chem. Commun. 2011, 47, 7230-7232. (Highlighted bySynfacts, 2011, 9, 0985; Abstracted by ChemInform, 2011, 42, 44-025)
Zhi-Qian Wang, Chen-Guo Feng, Shu-Sheng Zhang, Ming-Hua Xu* and Guo-Qiang Lin*, “Rhodium-Catalyzed Asymmetric Conjugate Addition of Organoboronic Acids to Nitroalkenes Using Chiral Bicyclo[3.3.0] Diene Ligands”, Angew. Chem. Int. Ed., 2010, 49, 5780-5783. (Highlighted by Synfacts, 2010, 11, 1275 and Organic Chemistry Portal, 2011, July, 18; Abstracted by ChemInform, 2010, 41, 50-068)
Guo-Qiang Lin,* Ming-Hua Xu, Yu-Wu Zhong and Xing-Wen Sun, “An Advance on Exploring N-tert-Butanesulfinyl -imines in Asymmetric Synthesis of Chiral Amines”, Acc. Chem. Res. 2008, 41, 831-840. (Abstracted by ChemInform, 2008, 39, 45-237; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI)
Zhi-Qian Wang, Chen-Guo Feng, Ming-Hua Xu*, and Guo-Qiang Lin*, “Design of C2-Symmetric Tetrahydropentalenes as New Chiral Diene Ligands for Highly Enantioselective Rh-Catalyzed Arylation of N-Tosylarylimines with Arylboronic Acids”, J. Am. Chem. Soc. 2007, 129, 5336-5337. (Highlighted by Synfacts, 2007, 08, 0847 and Organic Chemistry Portal; Abstracted by ChemInform, 2007, 38, 37-073; Top 1% highly cited paper in the field of Chemistry as of March/April 2017, data from ESI).
Xing-Wen Sun, Ming-Hua Xu* and Guo-Qiang Lin*, “Room-Temperature Highly Diastereoselective Zn-Mediated Allylation of Chiral N-tert-Butanesulfinyl Imines: Remarkable Reaction Condition Controlled Stereoselectivity Reversal”, Organic Letters 2006, 8, 4979-4982. (Highlighted by Chemistry.Org of the American Chemical Society as a “Heart Cut” (Dec 4, 2006); also highlighted by Synfacts, 2006, 12, 1266; Abstracted by ChemInform, 2007, 38, 10-029).
Yu-Wu Zhong, Yi-Zhou Dong, Kai Fang, Kenji Izumi, Ming-Hua Xu* and Guo-Qiang Lin*, “A Highly Efficient and Direct Approach for Synthesis of Enantiopure α-Amino Alcohols by Reductive Cross-Coupling of Chiral N-tert-Butanesulfinyl Imines with Aldehydes”, J. Am. Chem. Soc.2005, 127, 11956-11957. (Highlighted by Synfacts, 2005, 3, 0331 and Organic Chemistry Portal; Abstracted by ChemInform, 2005, 37, 01-088).
Yu-Wu Zhong, Ming-Hua Xu* and Guo-Qiang Lin, Samarium Diiodide-Induced Asymmetric Synthesis of Optically Pure Unsymmetrical Vicinal Diamines by Reductive Cross-Coupling of Nitrones with N-tert-Butanesulfinyl Imines. Organic Letters 2004, 6, 3953-3956. (Highlighted by Chemistry.Org of the American Chemical Society as a “Heart Cut” (Nov 15, 2004); also highlighted by Angew. Chem. Int. Ed. 2005, 44, 7833; Abstracted by ChemInform, 2005, 36, 06-080)