師資
個(gè)人簡介：
肖波，南方科技大學(xué)生物學(xué)系 教授,，博士生導(dǎo)師,，深圳市國家級科技領(lǐng)軍領(lǐng)軍人才?，F(xiàn)任擔(dān)任中國神經(jīng)科學(xué)學(xué)會理亊,、國家科技部項(xiàng)目評審專家,、教育部學(xué)位與研究生教育發(fā)展中心評審專家, 教育部科技發(fā)展中心評審專家, 國家自然科學(xué)基金委評審專家,，以及國家科技獎(jiǎng)勵(lì)評審專家,。主要從事神經(jīng)與精神疾病機(jī)理的細(xì)胞和分子生物學(xué)研究,，采用遺傳修飾小鼠制備人類疾病模型。作為首席科學(xué)家承擔(dān)“973重大科學(xué)研究計(jì)劃項(xiàng)目”,。主持國家自然科學(xué)基金生命科學(xué)部重點(diǎn)項(xiàng)目（2016-2020）,。在腦髓鞘發(fā)育、腦細(xì)胞能量代謝和抗氧化損傷研究領(lǐng)域處于世界領(lǐng)先水平,。已相繼在Developmental Cell, Nature Neuroscience, 及Neuron等國際著名雜志上發(fā)表論文20余篇,，被引用>4,600次。連續(xù)五年（2014-2018）被Elsevier(愛思唯爾)評為中國神經(jīng)科學(xué)領(lǐng)域高被引學(xué)者,。
研究領(lǐng)域：
◆神經(jīng)元-膠質(zhì)細(xì)胞相互功能調(diào)節(jié)在健康與疾病中的作用
◆少突膠質(zhì)細(xì)胞與髓鞘發(fā)育的分子調(diào)控,；
◆小膠質(zhì)細(xì)胞與神經(jīng)退行性病變/再生;
◆神經(jīng)細(xì)胞代謝和氧化應(yīng)激與神經(jīng)退行性病變。
工作經(jīng)歷：
1993年-1997年: 加拿大多倫多大學(xué) 博士后研究,；
1997年-2000年: 美國約翰·霍普金斯大學(xué)神經(jīng)科學(xué)系工作博士后,；
2000-20005: 美國約翰·霍普金斯大學(xué)神經(jīng)科學(xué)系Research Faculty；
2005-2018：四川大學(xué)教授; 華西醫(yī)院神經(jīng)發(fā)育與代謝研究室主任,；
2017-至今: 南方科技大學(xué)終生教授,。
學(xué)習(xí)經(jīng)歷：
1991/9 - 1993/7，北京醫(yī)科大學(xué),，免疫學(xué),，博士
1986/9 - 1989/7，華西醫(yī)科大學(xué),，免疫學(xué),，碩士
1979/9 - 1984/7,，華西醫(yī)科大學(xué)，臨床醫(yī)學(xué),，學(xué)士
所獲榮譽(yù)：
2019: 深圳市國家級科技領(lǐng)軍人才,；
2008-2014: 國家科技部“973”項(xiàng)目首席科學(xué)家；
2008: 四川省優(yōu)秀外籍教師
代表文章：
1.Yang W, Pang D, Du C, Jiang W, Luo L, Yu Z, Tang P, Xia X, Cui Y, Chen C, Liu Y, Wei Y-Q, Worley P.F, Xiao B*. Rheb1 controls mitochondrial energy metabolism by activating pyruvate dehydrogenase independently of mTORC1. Nature Communications, 2019, submitted
2. Tan H, Chen M, Xia X, Pang D, Du C, Yang W, Cui Y, Huang C, Jiang W, Li C, Shang H, Worley PF, Xiao B*. LanCL1 Promotes Motor Neuron Survival and Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice. Cell Death and Differentiation, 2019, submitted
3.Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017; 7;114(10):E1996-E2005.
4.Ahuja M, Schwartz DM, Tandon M, Son A, Zeng M, Swaim W, Eckhaus M, Hoffman V, Cui Y, Xiao B, Worley PF, Muallem S Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity. Cell Metabolism. 2017 Mar 7;25(3):635-646.
5.Eunchai Kang, Ju Young Kim, Cindy Y Liu, Bo Xiao, Po Yu Chen, Kimberly M Christian, Paul F Worley, Hongjun Song, Guo-li Ming Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus. Neurogenesis 2015; 2(1)
6.Zou Y, Jiang W, Zhang J, Bu J, Wang J, Zou J, Zhou L, Yu S, Yang W, Luo L, Lu QR, Liu Y, Chen M, Worley PF, Xiao B*. Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain. Journal of Neuroscience. 2014, 34(47):15764-15778
7.Huang C, Chen M, Pang D, Bi D, Zou Y, Xia X, Yang W, Luo L, Deng R, Tan H, Zhou L, Yu S, Guo L, Du X, Cui Y, Hu J, Mao Q, Worley PF, Xiao B*. Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival. Developmental Cell. 2014;30(4): 479-487 (Featured Article)
8.Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PU, Worley PF, Bo Xiao*. Rheb1 is Required for mTORC1 and Myelination in Postnatal Brain Development. Developmental Cell. 2011;20(1):97-108
9.Han L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, Lamotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch. Nature Neuroscience, 2013; 16(2):174-82
10.Cao Y, Tao L, Shen S, Xiao J, Wu H, Li B, Wu X, Luo W, Xiao Q, Hu X, Liu H, Nie J, Lu S, Yuan B, Han Z, Xiao B, Yang Z, Li X. Cardiac ablation of Rheb1 induces impaired heart growth, endoplasmic reticulum-associated apoptosis and heart failure in infant mice. Int J Mol Sci. 2013;14(12):24380-98.
11.Park JM, Hu JH, Milshteyn A, Zhang PW, Moore CG, Park S, Datko MC, Domingo RD, Reyes CM, Wang XJ, Etzkorn FA, Xiao B, Szumlinski KK, Kern D, Linden DJ, Worley PF. A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell 2013;154(3):637-50
12.Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, Liu S, Jaramillo TC, Bangash M, Xiao B, Worley PF, and Powell CM. Loss of Predominant Shank3 Isoforms Results in Hippocampus-Dependent Impairments in Behavior and Synaptic Transmission. Journal of Neuroscience 2013, 33(47): 18448-18468
13.Obara I, Goulding SP, Gould AT, Lominac KD, Hu JH, Zhang PW, von Jonquieres G, Dehoff M, Xiao B, Seeburg PH, Worley PF, Klugmann M, Szumlinski KK. Homers at the Interface between Reward and Pain. Front Psychiatry. 2013; 7;4:39
14. Hu JH,，Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. Preso1 dynamically regulates group I Metabotropic glutamate receptors. Nature Neuroscience, 2012;15(6),836-844
15.Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, Xiao B, Worley PF, Powell JD. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nature Immunology. 2011; 12(4):295-303
16.Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ. SRF binding to SRE 6.9 in the Arc promoter is essential for the late phase of LTD in cultured cerebellar Purkinje cells. Nature Neuroscience. 2010;13(9): 1082-1089
17.Hu JH, Park JM, Park S, Xiao B, Dehoff MD, Kim S, Hayashi T, Schwarz M, Huganir RL, Seeburg PH, Linden DJ, Worley PF. Homeostatic Scaling requires Group I mGluR activation mediated by Homer1a Neuron. 2010;68(6):1128-1142
18.Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009;30(6):832-844
19.Ango F, Prezeau L, Muller T, Tu JC, Xiao B, Worley PF, Pin JP, Bockaert J, Fagni L. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature. 2001;411(6840):962-965
20.Xiao B, Tu JC, Worley PF. Homer: a link between neural activity and glutamate receptor function (invited). Curr Opin Neurobiol. 2000;10(3):370-374
21.Xiao B, Tu JC, Petralia RS, Yuan JP, Doan A, Breder CD, Lanahan AA, Wenthold RJ, Worley PF. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998;21(4):707-716
22.Tu JC, Xiao B (co-first author), Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Lanahan AA, Sheng M, Worley PF. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron.1999;23(3):583-592
23.Tu JC, Xiao B (co-first author), Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 1998;21(4):717-726
24.Beneken J, Tu JC, Xiao B, Yuan JP, Worley PF, Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron. 2000;26(1):143-154