師資
個(gè)人簡(jiǎn)介
王松靈,，中國(guó)科學(xué)院院士,，中國(guó)醫(yī)學(xué)科學(xué)院學(xué)術(shù)咨詢委員會(huì)學(xué)部委員，全國(guó)政協(xié)委員優(yōu)秀履職獎(jiǎng)獲獎(jiǎng)?wù)?，講席教授,、主任醫(yī)師。任南方科技大學(xué)醫(yī)學(xué)院院長(zhǎng),，南方科技大學(xué)倫敦國(guó)王學(xué)院醫(yī)學(xué)院院長(zhǎng),，南方科技大學(xué)穩(wěn)態(tài)醫(yī)學(xué)院研究院院長(zhǎng)，首都醫(yī)科大學(xué)健康大數(shù)據(jù)國(guó)家研究院院長(zhǎng),，中華口腔醫(yī)學(xué)會(huì)副會(huì)長(zhǎng),，北京醫(yī)學(xué)會(huì)副會(huì)長(zhǎng)，口腔健康北京實(shí)驗(yàn)室主任,。國(guó)務(wù)院學(xué)位委員會(huì)第八屆口腔醫(yī)學(xué)召集人,；第六屆全國(guó)口腔教材評(píng)審委員會(huì)主任委員,；全國(guó)統(tǒng)編八年制及“5+3一體化”教材《口腔醫(yī)學(xué)》及《硝酸鹽與機(jī)體穩(wěn)態(tài)》等主編,；《中華口腔醫(yī)學(xué)雜志》總編輯、 Current Medicine 主編,、《醫(yī)學(xué)教育管理》主編,、 《今日口腔》主編。發(fā)表論文279篇,，其中以主要作者發(fā)表英文論文187篇,。 第一完成人獲2003及2010年國(guó)家科技進(jìn)步二等獎(jiǎng)兩項(xiàng)；獲威廉蓋茨（William J. Gies）獎(jiǎng),、吳階平醫(yī)藥創(chuàng)新獎(jiǎng),、何梁何利科學(xué)技術(shù)獎(jiǎng)。研究方向?yàn)榉€(wěn)態(tài)醫(yī)學(xué),，牙頜發(fā)育與再生,，唾液腺疾病診療。發(fā)現(xiàn)人細(xì)胞膜硝酸鹽轉(zhuǎn)運(yùn)通道,，創(chuàng)立并闡釋穩(wěn)態(tài)醫(yī)學(xué)的概念,，研發(fā)基于硝酸鹽的耐瑞特新藥；揭示牙發(fā)育新機(jī)制,，研發(fā)牙髓干細(xì)胞新藥,，成功實(shí)現(xiàn)生物性牙齒再生。
在2021年度全國(guó)政協(xié)委員優(yōu)秀履職獎(jiǎng)的頒獎(jiǎng)詞中是這么評(píng)價(jià)王松靈院士的：“一支筆寫提案,，踐行委員責(zé)任推進(jìn)慢病防治納入重大科技專項(xiàng),，精準(zhǔn)建言推動(dòng)醫(yī)學(xué)科技成果轉(zhuǎn)化。一支筆寫教案，傳道授業(yè)解惑培養(yǎng)杏壇翹楚,。懸壺濟(jì)世的醫(yī)者,、立德樹人的師者，更是協(xié)商議政的行家里手,?！币源藶樗麑?duì)中國(guó)醫(yī)學(xué)事業(yè)的建設(shè)及口腔醫(yī)學(xué)的創(chuàng)新發(fā)展做出的突出貢獻(xiàn)進(jìn)行表彰及肯定。
研究領(lǐng)域
穩(wěn)態(tài)醫(yī)學(xué),，牙頜發(fā)育與再生,，唾液腺疾病診療。
教育背景
1979年9月-1984年7月 北京大學(xué)口腔醫(yī)學(xué)院 口腔醫(yī)學(xué) 本科
1984年7月-1989年7月 北京大學(xué)口腔醫(yī)學(xué)院 口腔頜面外科及口腔放射 碩士/博士
1991年4月-1992年4月 日本東京醫(yī)科齒科大學(xué)研究生院 口腔醫(yī)學(xué) 訪問(wèn)學(xué)者
1996年11月-1998年5月 美國(guó)國(guó)立衛(wèi)生研究院（NIH） 口腔生物醫(yī)學(xué) 高級(jí)訪問(wèn)學(xué)者
2001年5月2001年9月 美國(guó)國(guó)立衛(wèi)生研究院（NIH） 國(guó)立牙顱頜研究所（NIDCR） 口腔生物醫(yī)學(xué) 高級(jí)訪問(wèn)學(xué)者
工作經(jīng)歷
1989年9月-1996年10月
首都醫(yī)科大學(xué)附屬北京口腔醫(yī)院放射科 主治醫(yī)師,、副主任,、副主任醫(yī)師、副教授
1996年10月-至今
首都醫(yī)科大學(xué)附屬北京口腔醫(yī)院 北京口腔醫(yī)學(xué)研究所 副所長(zhǎng),、主任醫(yī)師,、教授
1999年4月-2005年2月
首都醫(yī)科大學(xué)附屬北京口腔醫(yī)院 副院長(zhǎng)
2005年3月-至今
首都醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院生物化學(xué)與分子生物學(xué)系 副校長(zhǎng)（2005-2022）一級(jí)教授（2019-）
2020年-至今
首都醫(yī)科大學(xué)健康醫(yī)療大數(shù)據(jù)國(guó)家研究院 院長(zhǎng)
2011年9月-2013年3月
北京市衛(wèi)生局 副局長(zhǎng)（掛職）
2019年10月-至今
教育部 國(guó)家督學(xué)
2023年10月-至今
南方科技大學(xué)醫(yī)學(xué)院院長(zhǎng)
獲獎(jiǎng)情況及榮譽(yù)
第一完成人獲2003及2010年國(guó)家科技進(jìn)步二等獎(jiǎng)兩項(xiàng)
2018年北京市科技進(jìn)步一等獎(jiǎng)
獲國(guó)際口腔權(quán)威的威廉蓋茨（William J. Gies）獎(jiǎng)
獲吳階平醫(yī)藥創(chuàng)新獎(jiǎng)
中源協(xié)和生命醫(yī)學(xué)獎(jiǎng)-成就獎(jiǎng)、干細(xì)胞轉(zhuǎn)化成果獎(jiǎng),、何梁何利獎(jiǎng)
入圍Elsevier“中國(guó)高被引學(xué)者”榜
當(dāng)選英國(guó)皇家外科學(xué)院（愛丁堡）杰出Fellow
口腔醫(yī)學(xué)界首位獲國(guó)家杰出青年科學(xué)基金學(xué)者
首批入選北京學(xué)者
獲國(guó)家發(fā)明專利授權(quán)19項(xiàng),，美國(guó)發(fā)明專利授權(quán)4項(xiàng)
牽頭制定我國(guó)口腔醫(yī)學(xué)本科教育及實(shí)踐教育標(biāo)準(zhǔn)，為促進(jìn)口腔教育健康發(fā)展做出重要貢獻(xiàn),。
迄今已培養(yǎng)研究生126人,，其中“國(guó)家杰出青年科學(xué)基金”和“國(guó)家優(yōu)秀青年科學(xué)基金”獲得者4人。
主編《唾液腺非腫瘤疾病》,、《口腔頜面疾病臨床X線表現(xiàn)及其病理學(xué)基礎(chǔ)》等學(xué)術(shù)專著和《口腔醫(yī)學(xué)》,、《口腔分子生物學(xué)與口腔實(shí)驗(yàn)動(dòng)物模型》等本科生和研究生規(guī)劃教材。
近年代表文章
發(fā)表論文279篇,，其中以通訊作者發(fā)表英文論文187篇,，英文review article 16篇，主編教科書及專著22本,。
Chang, S., Hu, L., Xu, Y., Li, X., Ma, L., Feng, X., Wang, J., Zhang, C., & Wang, S. (2019). Inorganic nitrate alleviates total body irradiation-induced systemic damage by decreasing reactive oxygen species levels. International journal of radiation oncology, biology, physics, 103(4), 945–957.
Ding, G., Liu, Y., Wang, W., Wei, F., Liu, D., Fan, Z., An, Y., Zhang, C., & Wang, S. (2010). Allogeneic periodontal ligament stem cell therapy for periodontitis in swine. Stem cells (Dayton, Ohio), 28(10), 1829–1838.
Feng, X., Wu, Z., Xu, J., …… Wang, S. (2021). Dietary nitrate supplementation prevents radiotherapy-induced xerostomia. eLife. 2021b. https:// doi. org/10. 7554/ eLife. 70710.
Feng, Y., Cao, X., Zhao, B., …… Hu, J.Q., Wang, S. (2021) Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway. Sci China Life Sci. https:// doi. org/ 10. 1007/s11427- 020- 1978-4.
Gao, Z. H., Hu, L., Liu, G. L., Wei, F. L., Liu, Y., Liu, Z. H., Fan, Z. P., Zhang, C. M., Wang, J. S., & Wang, S. L. (2016). Bio-root and implant-based restoration as a tooth replacement alternative. Journal of dental research, 95(6), 642–649.
Hu, J., Cao, Y., Xie, Y., Wang, H., Fan, Z., Wang, J., Zhang, C., Wang, J., Wu, C. T., & Wang, S. (2016). Periodontal regeneration in swine after cell injection and cell sheet transplantation of human dental pulp stem cells following good manufacturing practice. Stem cell research & therapy, 7(1), 130.
Hu, L., Jin, L., Xia, D., Zhang, Q., Ma, L., Zheng, H., Xu, T., Chang, S., Li, X., Xun, Z., Xu, Y., Zhang, C., Chen, F., & Wang, S. (2020). Nitrate ameliorates dextran sodium sulfate-induced colitis by regulating the homeostasis of the intestinal microbiota. Free radical biology & medicine, 152, 609–621.
Hu, L., Xu, J., Wu, T., Fan, Z., Sun, L., Liu, Y., Li, Y., Zhang, C., Wang, J., Ding, Y., & Wang, S. (2020). Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sj?gren's syndrome. Cell death & disease, 11(3), 172.
Hu, L., Zhu, Z., Hai, B., Chang, S., Ma, L., Xu, Y., Li, X., Feng, X., Wu, X., Zhao, Q., Qin, L., Wang, J., Zhang, C., Liu, F., & Wang, S. (2018). Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model. Theranostics, 8(16), 4321–4331.
Jin, L., Qin, L., Xia, D., Liu, X., Fan, Z., Zhang, C., Gu, L., He, J., Ambudkar, I. S., Deng, D., & Wang, S. (2013). Active secretion and protective effect of salivary nitrate against stress in human volunteers and rats. Free radical biology & medicine, 57, 61–67.
Li, J., Shan, Z., Ou, G., Liu, X., Zhang, C., Baum, B. J., & Wang, S. (2005). Structural and functional characteristics of irradiation damage to parotid glands in the miniature pig. International journal of radiation oncology, biology, physics, 62(5), 1510–1516.
Li, S., Jin, H., Sun, G., Zhang, C., Wang, J., Xu, H., Zhang, D., & Wang, S. (2021). Dietary inorganic nitrate protects hepatic ischemia-reperfusion injury through NRF2-mediated antioxidative stress. Frontiers in pharmacology, 12, 634115.
Li, X.Y., …… Wang, S. (2024). Discovery of Sialin2 as the sensor of nitrate in the organelle membrane.
Liu, O., Xu, J., Ding, G., Liu, D., Fan, Z., Zhang, C., Chen, W., Ding, Y., Tang, Z., & Wang, S. (2013). Periodontal ligament stem cells regulate B lymphocyte function via programmed cell death protein 1. Stem cells (Dayton, Ohio), 31(7), 1371–1382.
Liu, Y., Hu J.T., Liu Y.T., …… Wu Z.Z., Wang, S. Clinical study and a phase I clinical trial of allogeneic human dental pulp stem cells injection in the treatment of chronic periodontitis.
Liu, Y., Zheng, Y., Ding, G., Fang, D., Zhang, C., Bartold, P. M., Gronthos, S., Shi, S., & Wang, S. (2008). Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem cells (Dayton, Ohio), 26(4), 1065–1073.
Ma, L., Hu, L., Jin, L., Wang, J., Li, X., Wang, W., Chang, S., Zhang, C., Wang, J., & Wang, S. (2020). Rebalancing glucolipid metabolism and gut microbiome dysbiosis by nitrate-dependent alleviation of high-fat diet-induced obesity. BMJ open diabetes research & care, 8(1), e001255.
Ma, L., Hu, J., Cao, Y., Xie, Y., Wang, H., Fan, Z., Zhang, C., Wang, J., Wu, C. T., & Wang, S. (2019). Maintained properties of aged dental pulp stem cells for superior periodontal tissue regeneration. Aging and disease, 10(4), 793–806.p
Qin, L., Liu, X., Sun, Q., Fan, Z., Xia, D., Ding, G., Ong, H. L., Adams, D., Gahl, W. A., Zheng, C., Qi, S., Jin, L., Zhang, C., Gu, L., He, J., Deng, D., Ambudkar, I. S., & Wang, S. (2012). Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America, 109(33), 13434–13439.
Pan,W., Hu, G., Li, S.R., …… Wang, X.G., Wang, Y.J., Wang, S. (2023). Nanonitrator: novel enhancer of inorganic nitrate’s protective effects, predicated on swarm learning approach. Science Bulletin,, 68: 838–850.
Shan, Z., Li, J., Zheng, C., Liu, X., Fan, Z., Zhang, C., Goldsmith, C. M., Wellner, R. B., Baum, B. J., & Wang, S. (2005). Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Molecular therapy : the journal of the American Society of Gene Therapy, 11(3), 444–451.
Song, T., Wu, T., Wei, F., Li, A., Wang, F., Xie, Y., Liu, D., Fan, Z., Wang, X., Cheng, S., Zhang, C., He, J., & Wang, S. (2014). Construction of a cDNA library for miniature pig mandibular deciduous molars. BMC developmental biology, 14, 16.
Sonoyama, W., Liu, Y., Fang, D., Yamaza, T., Seo, B. M., Zhang, C., Liu, H., Gronthos, S., Wang, C. Y., Wang, S., & Shi, S. (2006). Mesenchymal stem cell-mediated functional tooth regeneration in swine. PloS one, 1(1), e79.
Wang, F., Wu, Z., Fan, Z., Wu, T., Wang, J., Zhang, C., & Wang, S. (2018). The cell re-association-based whole-tooth regeneration strategies in large animal, Sus scrofa. Cell proliferation, 51(4), e12479.
Wang, F., Xiao, J., Cong, W., Li, A., Song, T., Wei, F., Xu, J., Zhang, C., Fan, Z., & Wang, S. (2014). Morphology and chronology of diphyodont dentition in miniature pigs, Sus Scrofa. Oral diseases, 20(4), 367–379.
Wang, F., Xiao, J., Cong, W., Li, A., Wei, F., Xu, J., Zhang, C., Fan, Z., He, J., & Wang, S. (2014). Stage-specific differential gene expression profiling and functional network analysis during morphogenesis of diphyodont dentition in miniature pigs, Sus Scrofa. BMC genomics, 15, 103.
Wang, H., Hu, L., Li, L., Wu, X., Fan, Z., Zhang, C., Wang, J., Jia, J., & Wang, S. (2018). Inorganic nitrate alleviates the senescence-related decline in liver function. Science China Life Sciences, 61(1), 24–34.
Wang, S., Qin, L.Z. (2022) Homeostatic medicine: a strategy for exploring health and disease. Current Medicine, 1:16 (https://doi.org/10.1007/s44194-022-00016-9).
Wang, W., Hu, L., Chang, S., Ma, L., Li, X., Yang, Z., Du, C., Qu, X., Zhang, C., & Wang, S. (2020). Total body irradiation-induced colon damage is prevented by nitrate-mediated suppression of oxidative stress and homeostasis of the gut microbiome. Nitric oxide : biology and chemistry, 102, 1–11.
Wei, F., Song, T., Ding, G., Xu, J., Liu, Y., Liu, D., Fan, Z., Zhang, C., Shi, S., & Wang, S. (2013). Functional tooth restoration by allogeneic mesenchymal stem cell-based bio-root regeneration in swine. Stem cells and development, 22(12), 1752–1762.
Wu, X., Hu, J., Li, G., Li, Y., Li, Y., Zhang, J., Wang, F., Li, A., Hu, L., Fan, Z., Lü, S., Ding, G., Zhang, C., Wang, J., Long, M., & Wang, S. (2020). Biomechanical stress regulates mammalian tooth replacement via the integrin β1-RUNX2-Wnt pathway. The EMBO journal, 39(3), e102374.
Wu, Y., Zhang, J., Peng, B., Tian, D., Zhang, D., Li, Y., Feng, X., Liu, J., Li, J., Zhang, T., Liu, X., Lu, J., Chen, B., & Wang, S. (2019). Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos. Nature communications, 10(1), 2883.
Wu, Z., Wang, F., Fan, Z., Wu, T., He, J., Wang, J., Zhang, C., & Wang, S. (2019). Whole-tooth regeneration by allogeneic cell reassociation in pig jawbone. Tissue engineering. Part A, 25(17-18), 1202–1212.
Xia, D. S., Deng, D. J., & Wang, S. L. (2003). Destruction of parotid glands affects nitrate and nitrite metabolism. Journal of dental research, 82(2), 101–105.
Xu, J., Wang, D., Liu, D., Fan, Z., Zhang, H., Liu, O., Ding, G., Gao, R., Zhang, C., Ding, Y., Bromberg, J. S., Chen, W., Sun, L., & Wang, S. (2012). Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sj?gren syndrome. Blood, 120(15), 3142–3151.
Zhu, Z., Pang, B., Iglesias-Bartolome, R., Wu, X., Hu, L., Zhang, C., Wang, J., Gutkind, J. S., & Wang, S. (2016). Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands. Oncotarget, 7(15), 20271–20281.