師資
個人簡介:
帥世民,,南方科技大學醫(yī)學院人類細胞生物和遺傳學系副教授,、博士生導(dǎo)師,,獲深圳市人才頭銜,。2014年本科畢業(yè)于浙江大學生命科學學院,2019年博士畢業(yè)于多倫多大學分子遺傳學系和安大略省癌癥研究所(OICR),,后赴歐洲分子生物學實驗室海德堡總部(EMBL-Heidelberg)和歐洲生物信息學研究所(EMBL-EBI)進行由歐盟瑪麗·居里學者(MSCA)項目聯(lián)合資助的博士后研究(EIPOD4),并于2021年秋季全職回國組建計算組學(Computational Omics,,COmics)實驗室,。主要從事計算生物學、生物信息學,、基因組學等領(lǐng)域的研究,。其關(guān)于癌癥基因組學、計算組學工具研發(fā)等的研究以第一或通訊作者身份發(fā)表在了Nature及其子刊上,。截至2022年5月累計發(fā)表論文12篇,,相關(guān)論文總被引超過1600次,h-index為10,。
教育背景:
· 2014.9-2019.11:多倫多大學,,計算生物學,博士,,導(dǎo)師Lincoln Stein,,加拿大
· 2010.9-2014.6:浙江大學,生物科學,,本科,,中國
工作經(jīng)歷:
· 2022.6-至今:南方科技大學,醫(yī)學院,人類細胞生物和遺傳學系,,副教授,,中國
· 2021.9-2022.5:南方科技大學,醫(yī)學院,,人類細胞生物和遺傳學系,,助理教授,中國
· 2020.10-2021.8:歐洲生物信息學研究所(EMBL-EBI),,聯(lián)合博士后,,導(dǎo)師Ewan Birney,英國
· 2020.1-2021.8:歐洲分子生物學實驗室(EMBL),,EIPOD4博士后(瑪麗·居里學者聯(lián)合資助),,導(dǎo)師Jan Korbel,德國
· 2015.1-2019.11:安大略省癌癥研究所(OICR),,計算生物學項目,,博士生研究員,導(dǎo)師Lincoln Stein,,加拿大
獲獎情況及榮譽:
· 2021:深圳市高層次人才(國家級領(lǐng)軍人才)
· 2020:EMBL Interdisciplinary Postdoctoral Fellowship (EIPOD4) co-funded by Marie-Sk?odowska Curie Actions
· 2019:Canadian Cancer Society Travel Award
研究領(lǐng)域:
1. 生物信息學和計算生物學
2. 全尺度遺傳變異與人類疾病的關(guān)聯(lián)
3. RNA異常剪接與人類疾病的關(guān)聯(lián)
4. 疾病生態(tài)系統(tǒng)研究
5. 多組學數(shù)據(jù)分析與新型組學數(shù)據(jù)分析工具研發(fā)
發(fā)表論文:
1. Shuai S*, PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein LD* & PCAWG Consortium (2020) Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat. Commun. 11: 734–734
2. Shuai S, Suzuki H, Diaz-Navarro A, Nadeu F, Kumar SA, Gutierrez-Fernandez A, Delgado J, Pinyol M, López-Otín C, Puente XS, Taylor MD, Campo E & Stein LD (2019) The U1 spliceosomal RNA is recurrently mutated in multiple cancers. Nature 574: 712–716
3. Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O, Tiao G, Hornsh?j H, Hess JM, Juul RI, Lin Z, Feuerbach L, Sabarinathan R, Madsen T, Kim J, Mularoni L, Shuai S, Lanzós A, Herrmann C, Maruvka YE, Shen C, et al (2020) Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature 578: 102–111
4. Zhu H, Uusküla-Reimand L, Isaev K, Wadi L, Alizada A, Shuai S, Huang V, Aduluso-Nwaobasi D, Paczkowska M, Abd-Rabbo D, Ocsenas O, Liang M, Thompson JD, Li Y, Ruan L, Krassowski M, Dzneladze I, Simpson JT, Lupien M, Stein LD, et al (2020) Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks. Mol. Cell 77: 1-15
5. Suzuki H, Kumar SA, Shuai S, Diaz-Navarro A, Gutierrez-Fernandez A, De Antonellis P, Cavalli FMG, Juraschka K, Farooq H, Shibahara I, Vladoiu MC, Zhang J, Abeysundara N, Przelicki D, Skowron P, Gauer N, Luu B, Daniels C, Wu X, Forget A, et al (2019) Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma. Nature 574: 707–711
6. Feigin ME, Garvin T, Bailey P, Waddell N, Chang DK, Kelley DR, Shuai S, Gallinger S, McPherson JD, Grimmond SM, Khurana E, Stein LD, Biankin AV, Schatz MC & Tuveson DA (2017) Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma. Nat. Genet. 49: 825–833
7. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium [including Shuai S] (2020) Pan-cancer analysis of whole genomes. Nature 578: 82–93
8. Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS, PCAWG Drivers and Functional Interpretation Group [including Shuai S], Johnson R & PCAWG Consortium (2020) Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Communications biology 3: 56–56
9. Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J & PCAWG Consortium (2020) Integrative pathway enrichment analysis of multivariate omics data. Nat. Commun. 11: 735–735
10. Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, Wheeler DA, Brunak S, Izarzugaza JMG, Khurana E, Marchal K, et al, PCAWG Drivers and Functional Interpretation Working Group [including Shuai S], Reimand J, Stuart JM, Raphael BJ & PCAWG Consortium (2020) Pathway and network analysis of more than 2500 whole cancer genomes. Nat. Commun. 11: 729–729