師資
個(gè)人簡(jiǎn)介：
陳默,，醫(yī)學(xué)院藥理學(xué)系副教授。2013年于新加坡國(guó)立大學(xué)（National University of Singapore）獲得博士學(xué)位,，2014-2017年于新加坡國(guó)立大學(xué)從事博士后研究,。2017年-2023年于美國(guó)威斯康星大學(xué)麥迪遜分校（University of Wisconsin Madison）相繼任博士后和專職研究員。2023年4月加入南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系,。主要研究方向?yàn)榧?xì)胞器中脂代謝信號(hào)通路的分子機(jī)制,，包括轉(zhuǎn)脂蛋白、磷酸肌醇代謝,、脂質(zhì)與蛋白質(zhì)復(fù)合體,、脂質(zhì)效應(yīng)蛋白及相關(guān)疾病機(jī)理。作為第一/共同第一作者在細(xì)胞生物學(xué)權(quán)威期刊Nature Cell Biology 發(fā)表論文三篇, Cell Death & Differentiation發(fā)表論文兩篇,，共發(fā)表SCI論文13篇,。
教育背景：
2009-08 至 2013-12, 新加坡國(guó)立大學(xué), 生物學(xué), 博士
2005-09 至 2009-06, 四川大學(xué), 生物技術(shù), 學(xué)士
工作經(jīng)歷：
2023-04至今 南方科技大學(xué)醫(yī)學(xué)院藥理學(xué)系，助理教授
2022-07至 2023-03 美國(guó)威斯康星大學(xué)麥迪遜分校醫(yī)學(xué)院, Senior Scientist
2019-09至 2022-07 美國(guó)威斯康星大學(xué)麥迪遜分校醫(yī)學(xué)院, Associate Scientist
2017-07至 2019-09 美國(guó)威斯康星大學(xué)麥迪遜分校醫(yī)學(xué)院, 博士后
2014-01至 2017-06 新加坡國(guó)立大學(xué)生物系,，博士后
獲獎(jiǎng)情況及榮譽(yù)：
2015 新加坡心血管協(xié)會(huì)優(yōu)秀青年學(xué)者獎(jiǎng)勵(lì)
2009-2013 新加坡國(guó)立大學(xué)全額獎(jiǎng)學(xué)金
2009 四川省優(yōu)秀大學(xué)畢業(yè)生
2007 國(guó)家獎(jiǎng)學(xué)金
研究領(lǐng)域：
本課題組將利用生物化學(xué),、細(xì)胞生物學(xué),、質(zhì)譜等多種方法來研究脂代謝信號(hào)調(diào)控、脂質(zhì)在細(xì)胞器之間的運(yùn)輸,、脂質(zhì)與效應(yīng)蛋白的復(fù)合及生物學(xué)功能,，了解脂質(zhì)在細(xì)胞器中的非膜結(jié)構(gòu)上的定位以及作用機(jī)理，解析疾病中的脂代謝功能異常并以此為靶點(diǎn)開發(fā)新型藥物,。
發(fā)表論文：
1. Chen, M., Choi, S., Wen, T., Chen, C., Thapa, N., Lee, J. H., Cryns, V. L. & Anderson, R. A. A p53-phosphoinositide signalosome regulates nuclear AKT activation. Nat Cell Biol 24, 1099-1113 (2022). https://doi.org:10.1038/s41556-022-00949-1
2. Thapa, N.#, Chen, M.# (#共同一作), Horn, H. T., Choi, S., Wen, T. & Anderson, R. A. Phosphatidylinositol-3 kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4. Nat Cell Biol 22, 1357-1370 (2020). https://doi.org:10.1038/s41556-020-00596-4
3. Choi, S.#, Chen, M.# (#共同一作), Cryns, V. L. & Anderson, R. A. A nuclear phosphoinositide kinase complex regulates p53. Nat Cell Biol 21, 462-475 (2019). https://doi.org:10.1038/s41556-019-0297-2
4. Chen, M., Qiu, T., Wu, J., Yang, Y., Wright, G. D., Wu, M. & Ge, R. Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs. Cell Death Differ 25, 1905-1920 (2018). https://doi.org:10.1038/s41418-018-0092-9
5. Chen, M., Zhang, Y., Yu, V. C., Chong, Y. S., Yoshioka, T. & Ge, R. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell Death Differ 21, 797-810 (2014). https://doi.org:10.1038/cdd.2014.3
6. Chen, M., Horn, H. T., Wen, T., Cryns, V. L. & Anderson, R. A. Assessing In Situ Phosphoinositide-Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells. Methods Mol Biol 2251, 133-142 (2021). https://doi.org:10.1007/978-1-0716-1142-5_9
7. Chen, M., Wen, T., Horn, H. T., Chandrahas, V. K., Thapa, N., Choi, S., Cryns, V. L. & Anderson, R. A. The nuclear phosphoinositide response to stress. Cell Cycle 19, 268-289 (2020). https://doi.org:10.1080/15384101.2019.1711316
8. Chen, M. #, Choi, S. .# (#共同一作), Jung, O. et al. The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif. Sci Rep 9, 9126 (2019). https://doi.org/10.1038/s41598-019-45671-5
9. Kumar, S. #, Chen, M.# (#共同一作), Li, Y., Wong, F. H., Thiam, C. W., Hossain, M. Z., Poh, K. K., Hirohata, S., Ogawa, H., Angeli, V. & Ge, R. Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice. Sci Rep 6, 31130 (2016). https://doi.org:10.1038/srep31130
10. Kao, C., Chandna, R., Ghode, A., Dsouza, C., Chen, M., Larsson, A., Lim, S. H., Wang, M., Cao, Z., Zhu, Y., Anand, G. S. & Ge, R. Proapoptotic Cyclic Peptide BC71 Targets Cell-Surface GRP78 and Functions as an Anticancer Therapeutic in Mice. EBioMedicine 33, 22-32 (2018). https://doi.org:10.1016/j.ebiom.2018.06.004
11. Venugopal, S., Kao, C., Chandna, R., Sulochana, K. N., Subramanian, V., Chen, M., Kini, R. M. & Ge, R. Angio-3, a 10-residue peptide derived from human plasminogen kringle 3, suppresses tumor growth in mice via impeding both angiogenesis and vascular permeability. Angiogenesis 21, 653-665 (2018). https://doi.org:10.1007/s10456-018-9616-7
12. Venugopal, S., Chen, M., Liao, W., Er, S. Y., Wong, W. S. & Ge, R. Isthmin is a novel vascular permeability inducer that functions through cell-surface GRP78-mediated Src activation. Cardiovasc Res 107, 131-142 (2015). https://doi.org:10.1093/cvr/cvv142
13. Zhang, Y., Chen, M., Venugopal, S., Zhou, Y., Xiang, W., Li, Y. H., Lin, Q., Kini, R. M., Chong, Y. S. & Ge, R. Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state. Cell Death Dis 2, e153 (2011). https://doi.org:10.1038/cddis.2011.37