師資
李逸明
研究教授
生物醫(yī)藥創(chuàng)新中心
E-mail: [email protected]
研究方向
用于生產(chǎn)重組蛋白的分子生物學(xué),、細(xì)胞生物學(xué)和生物化學(xué)技術(shù)的研發(fā)；蛋白質(zhì)純化、藥用蛋白質(zhì)質(zhì)量及穩(wěn)定性分析,；用于合成化學(xué)藥物及中間體的生物酶催化劑的研究及開(kāi)發(fā),；酶固定化技術(shù),。
教育經(jīng)歷
1994.08? – 1997.11? ?瑞典烏普薩拉大學(xué)生物化學(xué)系,，博士（獲生物化學(xué)博士學(xué)位）
1985.03? – 1988.08? ?中山大學(xué)生物系,，博士（獲動(dòng)物學(xué)博士學(xué)位）
1982.03? – 1985.01? ?中山大學(xué)生物系,，碩士
1978.03? – 1982.01? ?中山大學(xué)生物系,，學(xué)士
工作經(jīng)歷
2018.10 – 至今? ? ? ? ? 南方科技大學(xué)，研究教授
2016.10 – 2018.09? ? 美國(guó)Biosolutions-Plus,，首席科學(xué)官
2009.09 – 2016.08? ? 美國(guó)MedImmune（阿斯利康）,，科學(xué)家II
2002.05 – 2009.09? ? 美國(guó)人類基因組公司，科學(xué)家,、高級(jí)科學(xué)家
1998.08 – 2002.04? ? 哈佛大學(xué)醫(yī)學(xué)院,，博士后
1997.12 – 1998.07? ? 瑞典烏普薩拉大學(xué),，博士后
1990.01 – 1994.07? ? 烏瑞典普薩拉大學(xué)植物、卡洛林斯卡皇家醫(yī)學(xué)研究院,，博士后
1988.09 – 1989.12? ? 深圳市科委 科技交流中心,，工程師
代表性論文
1.?Li YM, Polozova A, Gruia F, and Feng J. (2014) Characterization of the degradation products of a color-changed monoclonal antibody: tryptophan-derived chromophores. Analytical Chemistry, 86: 6850-6857.
2.?Li YM, Stafford W, Hesselberg M, Hayes D, Wu Z. Byrne M. (2011) Characterization of the self-association of human interferon-α2b, albinterferon-α2b, and pegasys. Journal of Pharmaceutical Sciences. 101-1: 68–80
3.?Irwin N, Li YM, O’toole JE and Benowitz, L. (2006) Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth. Proc. Natl. Acad. Sci. USA 103(48): 18320-18325.
4.?Li YM, Irwin N, Yin YQ, Lanser M and Benowitz L. (2003) Axon regeneration in goldfish and rat retinal ganglion cells: differential responsiveness to carbohydrates and cAMP. J. Neurosci. 23 (21): 7830-7838.
5.?Liu CM, Li YM, Semenov M, Han C, Baeg GH, Tan Y, Zhang ZH, Lin XH and He X.? (2002) Control of ?-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847.
6.?Gottschalk I, Li YM and Lundahl P. (2000) Chromatography on cells: Analysis of solute interactions with the glucose transporter Glut 1 in human red cells adsorbed on lectin-gel beads. J Chromat B? Biomed Sci Appl. 739 (1) 55-62.
7.?Li YM, Liao JL, Zhang R, Henriksson H and Hjerten S. (1999) Continuous beds for microchromatography: chromatogocusing and anion exchange chromatography. Anal Biochem. 267 (1): 121-124.
8.?Li YM, Franklin G, Cui HM, Svensson K, He XB, Adam G, Ohlsson R and Pfeifer S. (1998) The H19 transcript is associated with polysomes and may regulate IGF2 expression in trans. J Biol Chem 273: 28247-28252.
9.?Hjerten S, Ericson C, Li YM and Zhang R. (1998) Capillary electrophoresis and capillary chromatography. Theoretical analogies and practical differences. Biomed Chromatogr.12: 120-121.
10.?Liao JL, Li YM and Hjerten S. (1996) Continuous beds for microchromatography: reversed phase chromatography. Anal Biochem. 234: 27-30.
11.?Li YM, Brostedt P, Hjerten S, Nyberg F and Silberring J. (1995) Capillary LC-FAB MS using a high-resolving cation-exchanger, based on a continuous chromatographic matrix. Application to studies on neuropeptide peptidases. J Chromatogr B. 664: 426-430.
12.?Li YM, Liao JL, Nakazato K, Mohammad J, Terenius L and Hjerten S. (1994) Continuous bed for microchromatography: cation-exchange chromatography. Anal Biochem. 223: 153-158.
13.?Silberring J, Li YM, Nyberg F. and Hjerten S. (1993) Strategies in studies on neuropeptide processing by mass spectrometry. Biochem Soc Trans. 22: 136-140.
14.?Mohammad J, Li YM, El-Ahman M, Nakazato K, Pettersson G and Hjerten S. 1993. Chiral-recognition chromatography of?b-blockers on continuous polymer beds with immobilized cellulase as enantioselective protein. Chirality 5: 464-470.
15.?Hjerten S, Li YM, Liao JL, Mohammad J, Nakazato K and Pettersson G. (1992) Continuous beds: high-resolving, cost-effective chromatographic matrices. Nature 356: 810-811.
16.?Jiang JB and Li YM (1988) Sarcocystosis induced by Sarcocystis suihominis in China. In “Zoonoses in China” (Yu ES and Xu BK eds.) pp.888-891.
17.?Li YM and Lian ZQ (1986) Studies on man-pig cyclic infection of Sarcocystis suihominis found in Yunnan Province, China. Acta Zoologica Sinica 32(4): 329-334.
專利
1.?中國(guó)專利(已提交)：通過(guò)點(diǎn)突變?cè)诋叧嘟湍钢斜磉_(dá)有活性的嗜熱脂肪芽胞桿菌脂肪酶。
申請(qǐng)人：王瑞工,、劉伊佳,、李逸明
2. 美國(guó)專利：Method of Purifying albumin-fusion proteins
申請(qǐng)人：Pabst, Timothy; Fonsecaf, Mariko; Thompson, Christopher
Hunter, Alan；Wang, Xiangyang,；Tie, Liu,；LI, Yiming
申請(qǐng)?zhí)枺篣S2016/022003
發(fā)表日期：2016年9月15日