師資
個人簡介：
田君，博士,，南方科技大學(xué)醫(yī)學(xué)院助理教授（獨立PI）,、副研究員,，博士生導(dǎo)師,。2018年博士畢業(yè)于加拿大麥吉爾大學(xué),，2019-2023年在美國哈佛醫(yī)學(xué)院麻省總醫(yī)院從事博士后研究,。2023年8月加入南方科技大學(xué)醫(yī)學(xué)院,。主要研究領(lǐng)域為癌癥的靶向和免疫治療,，在尋找藥物耐藥性的機(jī)制,，研究和開發(fā)新的聯(lián)合治療策略，腫瘤類器官模型的建立和藥物測試等方面取得了一系列成果,。近年來共發(fā)表SCI論文十余篇,，其中第一作者論文發(fā)表于Nature Medicine、British Journal of Cancer,、Breast Cancer Research等國際高水平期刊雜志,。曾獲得麥吉爾大學(xué)優(yōu)秀博士畢業(yè)生獎項，以及美國國立衛(wèi)生院和哈佛癌癥中心研究基金一項。擔(dān)任雜志Frontiers in Genetics審稿人,，以及美國癌癥研究協(xié)會會員,。
教育背景：
2009-2013 南開大學(xué)，學(xué)士
2013-2018 加拿大麥吉爾大學(xué),，博士
工作經(jīng)歷：
2023.08-至今 南方科技大學(xué)醫(yī)學(xué)院,，助理教授
2019-2023 美國哈佛醫(yī)學(xué)院麻省總醫(yī)院，博士后
2018-2019 加拿大麥吉爾大學(xué)健康中心,，博士后
獲獎情況及榮譽：
2018 加拿大麥吉爾大學(xué)優(yōu)秀博士畢業(yè)生獎
2017 加拿大麥吉爾大學(xué)醫(yī)學(xué)院優(yōu)秀生產(chǎn)力獎
研究領(lǐng)域：
基礎(chǔ)研究：（1）研究致癌信號通路對腫瘤免疫微環(huán)境的影響,；（2）研究腫瘤的靶向藥和免疫治療的協(xié)同作用；（3）腫瘤靶向藥物的耐藥機(jī)制,。以消化道腫瘤,，胰腺癌等為主要研究癌種。
臨床轉(zhuǎn)化應(yīng)用研究：通過發(fā)現(xiàn)新的腫瘤靶向藥和免疫治療的應(yīng)答/耐藥機(jī)制,，設(shè)計針對不同突變型（如KRAS突變）患者的藥物聯(lián)合治療方案,；尋找患者對藥物聯(lián)合治療反應(yīng)/耐藥的生物標(biāo)記物。
人源腫瘤類器官模型的建立：腫瘤藥物的療效評估,、機(jī)制研究和生物標(biāo)志物的發(fā)現(xiàn),。
學(xué)術(shù)任職：
雜志Frontiers in Genetics審稿人
美國癌癥研究協(xié)會會員
發(fā)表論文：
1. Jun Tian; Jonathan H. Chen; Sherry X. Chao; Karin Pelka; Marios Giannakis; Julian Hess; Kelly Burke; Vjola Jorgji; Princy Sindurakar; Jonathan Braverman; Arnav Mehta; Tomonori Oka; Mei Huang; David Lieb; Maxwell Spurrell; Jill N. Allen; Thomas A. Abrams; Jeffrey W. Clark; Andrea C. Enzinger; Peter C. Enzinger; Samuel J. Klempner; Nadine J. McCleary; Jeffrey A. Meyerhardt; David P. Ryan; Matthew B. Yurgelun; Katie Kanter; Emily E. Van Seventer; Islam Baiev; Gary Chi; Joy Jarnagin; William B. Bradford; Edmond Wong; Alexa G. Michel; Isobel J. Fetter; Giulia Siravegna; Angelo J. Gemma; Arlene Sharpe; Shadmehr Demehri; Rebecca Leary; Catarina D. Campbell; Omer Yilmaz; Gad A. Getz; Aparna R. Parikh; Nir Hacohen; Ryan B. Corcoran ; Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial, Nature Medicine, 2023, 29: 458-466
2. Yi Sun; Or-yam Revach; Seth Anderson; Emily A. Kessler; Clara H. Wolfe; Anne Jenney; Caitlin E. Mills; Emily J. Robitschek; Thomas G. R. Davis; Sarah Kim; Amina Fu; Xiang Ma; Jia Gwee; Payal Tiwari; Peter P. Du; Princy Sindurakar; Jun Tian; Arnav Mehta; Alexis M. Schneider; Keren Yizhak; Moshe Sade-Feldman; Thomas LaSalle; Tatyana Sharova; Hongyan Xie; Shuming Liu; William A. Michaud; Rodrigo Saad-Beretta; Kathleen B. Yates; Arvin Iracheta-Vellve; Johan K. E. Spetz; Xingping Qin; Kristopher A. Sarosiek; Gao Zhang; Jong Wook Kim; Mack Y. Su; Angelina M. Cicerchia; Martin Q. Rasmussen; Samuel J. Klempner; Dejan Juric; Sara I. Pai; David M. Miller; Anita Giobbie-Hurder; Jonathan H. Chen; Karin Pelka; Dennie T. Frederick; Susanna Stinson; Elena Ivanova; Amir R. Aref; Cloud P. Paweletz; David A. Barbie; Debattama R. Sen; David E. Fisher; Ryan B. Corcoran; Nir Hacohen; Peter K. Sorger; Keith T. Flaherty; Genevieve M. Boland; Robert T. Manguso; Russell W. Jenkins ; Targeting TBK1 to overcome resistance to cancer immunotherapy, Nature, 2023, 615(7950): 158-167
3. Tian, Jun; Wang, Vivian; Wang, Ni; Khadang, Baharak; Boudreault, Julien; Bakdounes, Khldoun; Ali, Suhad; Lebrun, Jean-Jacques ; Identification of MFGE8 and KLK5/7 as mediators of breast tumorigenesis and resistance to COX-2 inhibition, BREAST CANCER RESEARCH, 2021, 23(1)
4. Shams, Anwar; Binothman, Najat; Boudreault, Julien; Wang, Ni; Shams, Fuad; Hamam, Dana; Tian, Jun; Moamer, Alaa; Dai, Meiou; Lebrun, Jean-Jacques; Ali, Suhad ; Prolactin receptor-driven combined luminal and epithelial differentiation in breast cancer restricts plasticity, stemness, tumorigenesis and metastasis, ONCOGENESIS, 2021, 10(1)
5. Jun Tian; Fatmah Al Raffa; Meiou Dai; Alaa Moamer; Baharak Khadang; Ibrahim Y.Hachim; Khldoun Bakdounes; Suhad Ali; Bertrand Jean-Claude; Jean-Jacques Lebrun ; Dasatinib sensitises triple negative breast cancer cells to chemotherapy by targeting breast cancer stem cells, British Journal of Cancer, 2018, 119(12): 1495-1507
6. Jun Tian; Amal A.Al-Odaini; Yun Wang; Juliana Korah; Meiou Dai; Lan Xiao; Suhad Ali; Jean-Jacques Lebrun ; KiSS1 gene as a novel mediator of TGFβ-mediated cell invasion in triple negative breast cancer, Cellular Signalling, 2018, 42: 10
7. Jun Tian; Mahmood Y.Hachim; Ibrahim Y.Hachim; Meiou Dai; Chieh Lo; Fatmah Al Raffa; Suhad Ali; Jean Jacques Lebrun ; Cyclooxygenase-2 regulates TGFβ-induced cancer stemness in triplenegative breast cancer, Scientific Reports, 2017, 7: 40258
8. Hongru Zhang; Zheng Li; Li Wang; Gaofei Tian; Jun Tian; Zishan Yang; Guangchao Cao; Hong Zhou; Liqing Zhao; Zhenzhou Wu; Zhinan Yin ; Critical Role of Myeloid-Derived Suppressor Cells in Tumor-Induced Liver Immune Suppression through Inhibition of NKT Cell Function, Frontiers in Immunology, 2017, 8(129)
9. Laure Humbert; Mostafa Ghozlan; Lucie Canaff; Jun Tian; Jean-Jacques Lebrun ; The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma, BMC Cancer, 2015, 15(1): 200
10. Jimin Guo; Lucie Canaff; Charles Vincent Rajadurai; Nadège Fils-Aimé; Jun Tian; Meiou Dai; Juliana Korah; Manuel Villatoro; Morag Park; Suhad Ali; Jean-Jacques Lebrun ; Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes, Breast Cancer Research, 2014, 16(6): 476