師資
個(gè)人簡(jiǎn)介：
賈寧,，醫(yī)學(xué)院副教授,，博士生導(dǎo)師,。入選《麻省理工科技評(píng)論》“35歲以下科技創(chuàng)新35人”亞太區(qū)榜單（2022）,，美國(guó)布拉瓦尼克區(qū)域青年科學(xué)家化學(xué)獎(jiǎng)獲得者（2020）,。加入Journal of Biological Chemistry (JBC)期刊作為Editorial Board member (2024)。2016年于中國(guó)科學(xué)技術(shù)大學(xué)生命學(xué)院獲得博士學(xué)位,，師從周叢照/陳宇星教授,。2017-2021年在美國(guó)紀(jì)念斯隆凱特琳癌癥中心從事博士后研究，導(dǎo)師是美國(guó)兩院院士Dinshaw J. Patel教授,。2021年5月加入南方科技大學(xué)醫(yī)學(xué)院,。主要研究興趣為微生物與宿主免疫系統(tǒng)相互作用的分子機(jī)制。近年來(lái)以第一作者身以及通訊作者身份（含共同）發(fā)表論文16篇 (Nature Chemical Biology 2024,；Molecular Cell 2023,，2019a, 2019b, 2019c；Nature Communications, 2024a,b, 2022; Science, 2020; Nature Reviews Molecular Cell Biology, 2021,； Cell Research, 2024, 2022, 2020; PNAS, 2019等),。其中，13篇為通訊作者,。Nature Communications, 2022 被世界學(xué)術(shù)組織“Faculty Opinions (原F1000Prime)”推薦,；作為第一作者兼共同通訊作者發(fā)表綜述文章 (Nature Reviews Molecular Cell biology, 2021),。主持國(guó)自然面上、省市基金多項(xiàng),。擔(dān)任Nature,、Nature Catalysis、Nature Chemical Biology,、Nature Communications 等雜志審稿人,。
教育背景：
2006-2010 中國(guó)海洋大學(xué)，學(xué)士
2010-2016 中國(guó)科學(xué)技術(shù)大學(xué),，博士 （導(dǎo)師：周叢照,、陳宇星教授）
工作經(jīng)歷：
2022.06-至今 南方科技大學(xué)醫(yī)學(xué)院，副教授
2021.05-2022.05 南方科技大學(xué)醫(yī)學(xué)院,，助理教授
2017-2021 美國(guó)紀(jì)念斯隆凱特琳癌癥中心,，博士后 （導(dǎo)師：Dinshaw J. Patel）
獲獎(jiǎng)情況及榮譽(yù)：
2024 入選Journal of Biological Chemistry (JBC)期刊的Editorial Board member
2022 入選《麻省理工科技評(píng)論》“35歲以下科技創(chuàng)新35人”亞太區(qū)榜單（2022）
2020 美國(guó)布拉瓦尼克區(qū)域青年科學(xué)家化學(xué)獎(jiǎng) (2020 Blavatnik Regional Awards for Young Scientists Winner in Chemistry)
2016 蔡司-斑馬魚(yú)科學(xué)研究獎(jiǎng)
2010 山東省優(yōu)秀畢業(yè)生
2007，2009 國(guó)家獎(jiǎng)學(xué)金
研究興趣：
1）課題組通過(guò)結(jié)合生物化學(xué),、分子生物學(xué),、微生物學(xué)及結(jié)構(gòu)生物學(xué)等手段，探究微生物與宿主免疫系統(tǒng)相互作用的分子機(jī)制,，尤其關(guān)注細(xì)菌和古菌免疫系統(tǒng)（如CRISPR-Cas適應(yīng)性免疫系統(tǒng)）抵御噬菌體和質(zhì)粒入侵的分子機(jī)制,。
2）基于微生物與宿主免疫系統(tǒng)相互作用分子機(jī)制的理解，開(kāi)發(fā)相應(yīng)的生物技術(shù)工具（如CRISPR-Cas基因編輯工具）,。
學(xué)術(shù)任職：
Journal of Biological Chemistry (JBC)期刊的Editorial Board member
紐約科學(xué)學(xué)會(huì)（The New York Academy of Sciences）會(huì)員
發(fā)表論文：
（#第一作者; *通訊作者 ）
1. Zhang, J.T., Wei, X.Y., Cui, N., Tian, R. & Jia, N. * （2024）Target ssDNA activates the NADase activity of prokaryotic SPARTA immune system. Nature Chemical Biology 20, 503-511 .
2. Cui, N. et al.(2024）Tetramerization-dependent activation of the Sir2-associated short prokaryotic Argonaute immune system. Nature Communications 15, 8610 .
3. Duan, Z. et al. （2024）Structure and genome editing activity of the novel CRISPR-Cas12o1 effector. Cell Research . doi: 10.1038/s41422-024-01050-y.
4. Zhang, J.T.#, Liu, X.Y.#, Li, Z.L.#, Wei, X.Y., Song, X.Y., Cui, N., Zhong, J., Li, H., and Jia, N.* (2024). Structural basis for phage-mediated activation and repression of bacterial DSR2 anti-phage defense system. Nature Communications 15, 2797. 10.1038/s41467-024-47177-9.
5. Cui, N.#, Zhang, J.T.#, Li, Y., Liu, Y., Liu, X.Y., Wang, C., Huang, H.*, and Jia, N.* (2023). Type IV-A CRISPR-Csf complex: assembly, dsDNA targeting and CasDinG recruitment. Molecular Cell 83, 2493-2508 e2495.
6. Duan, Z.#, Zhang, X.#, Zhang, J.T., Li, S, Liu, R., Sun, J., Zhao, Q., Jia, N., Jia, N.*, and Zhu, J.K.* (2023). Molecular basis for DNA cleavage by the hypercompact Cas12j-SF05. Cell Discovery 9, 117. 10.1038/s41421-023-00612-5.
7. Cui, N.#, Zhang, J.T.#, Li, Z., Liu, X.Y.,Wang, C., Huang, H.*, and Jia, N.* (2022). Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase. Nature Communications 13, 7549.
8. Patel, D.J.*, Yu, Y., and Jia, N. (2022). Bacterial origins of cyclic nucleotide-activated antiviral immune signaling. Molecular Cell 82, 4591-4610.
9. Jia, N.* & Patel, D.J.* Structure-based evolutionary relationship between IscB and Cas9. Cell Research 32, 875-877 (2022).
10. Jia, N.*, Patel. D. J.*. (2021) Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins. Nature reviews. Molecular Cell Biology 22, 563-579, doi:10.1038/s41580-021-00371-9.
11. Meeske A. J.#, Jia, N.#, Cassel A.K., Kozlova A., Liao J., Wiedmann M., Patel D. J.*, Marraffini L. A.*. (2020) A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity. Science 369, 54-59.
12. Jia, N.*, Xie, W., De La Cruz, J.M., Eng, E.T., Patel, D.J.* (2020) Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Research 30, 182-184.
13. Jia, N.*, Jones, R., Yang, G., Ouerfelli, O., Patel, D.J.* (2019). CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity. Molecular Cell 75, 944-956 e946.
14. Jia, N.*, Jones, R., Sukenick, G., Patel, D.J.* (2019) Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path. Molecular Cell 75, 933-943 e936.
15. Jia, N.*, Mo, C.Y., Wang, C., Eng, E.T., Marraffini, L.A., Patel, D.J.* (2019). Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity. Molecular Cell 73, 264-277 e265.
16. Jia, N.#, Unciuleac, M.#, Xue C., Greene E.C., Patel, D.J.*, Shuman, S.* (2019) Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America 116, 24507-24516.
17. Jia, N., Liu, N., Cheng, W., Jiang, Y.L., Sun, H., Chen, L.L., Peng, J., Zhang, Y., Ding, Y.H., Zhang, Z.H., et al. (2016). Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein. EMBO reports 17, 235-248.
18. Chen, L.L., Xie, J., Cao, D.D., Jia, N., Li, Y.J., Sun, H., Li, W.F., Hu, B., Chen, Y., Zhou, C.Z. (2018). The pore-forming protein Aep1 is an innate immune molecule that prevents zebrafish from bacterial infection. Dev Comp Immunol 82, 49-54.
19. Zhou, K., Jia, N., Hu, C., Jiang, Y.L., Yang, J.P., Chen, Y., Li, S., Li, W.F., Zhou, C.Z. (2014). Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins 82, 3224-3229.
20. Song, N., Jia, N., Yanagimoto, T., Lin, L., Gao, T. (2013). Genetic differentiation of Trachurus japonicus from the Northwestern Pacific based on the mitochondrial DNA control region. Mitochondrial DNA 24, 705-712.
21. He, Y.X., Zhang, N.N., Li, W.F., Jia, N., Chen, B.Y., Zhou, K., Zhang, J., Chen, Y., Zhou, C.Z. (2012). N-Terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease. Journal of molecular biology 418, 197-207.
已申請(qǐng)專(zhuān)利:
賈寧,，黃鴻達(dá)，崔寧,，張峻濤,， 一種IV型CRISPR-Csf復(fù)合物、載體系統(tǒng),，202211033009.3,， 2022-08-26