師資
個人簡介:
黃安誠博士于2014年底在澳大利亞阿德萊德大學獲得天然產(chǎn)物化學博士學位,。2015年在澳門科技大學中藥質(zhì)量國家重點實驗室從事短暫工作后,,獲得歐盟瑪麗居里個人獎金的資助在英國約翰英納斯中心從事博士后工作,,2019年8月全職回國加入南方科技大學生物系任助理教授,。黃博士一直致力于植物代謝和天然產(chǎn)物研究。研究成果已發(fā)表在Science,, PNAS和 Angew. Chem. In. Ed. 等國際主流期刊上,,一作文章總影響因子85。
研究領域:
(1) 天然產(chǎn)物生物合成途徑發(fā)現(xiàn)與解析
(2) 植物功能基因組學和代謝組學
(3) 合成生物學和代謝工程
(4) 酶學催化反應機理和酶工程改造
(5) 小分子化合物介導的植物-微生物互作
工作經(jīng)歷:
2019.08 - 至今,,南方科技大學生物系,,副教授
2015 - 2019,英國約翰英納斯中心,,博士后
2015,,澳門科技大學中藥質(zhì)量控制國家重點實驗室,博士后
學習經(jīng)歷:
2010-2014,,澳大利亞阿德萊德大學,,博士
2009-2010,華南理工大學,,碩士研究生
2005-2009,,華南農(nóng)業(yè)大學,學士
Honors & Awards:
2016,,歐盟瑪麗居里學者
2014,,阿德萊德大學院長卓越博士論文獎
2009, 華南農(nóng)業(yè)大學‘紅滿堂’優(yōu)秀本科生
代表文章:
1.Huang, A.C.#; Jiang, T.#; Liu, Y.X.; Bai, Y.C.; Reed, J.; Qu, B; Goossens, A.; Nutzmann, H.-W.; Bai, Y.; Osbourn, A. A specialized metabolic network selectively modulates Arabidopsis root microbiota. Science, 2019, 364(6440): eaau6389. (# Co-first author)
2.Huang, A.C., Osbourn, A. Plant terpenes that mediate below‐ground interactions: prospects for bioengineering terpenoids for plant protection. Pest Management Science, 2019, DOI:10.1002/ps.5410.
3.Huang, A.C.; Hong, Y. J.; Bond, A. D.; Tantillo, D. J.; Osbourn, A. Diverged terpene synthases reroute the carbocation cyclization path towards the formation of unprecedented 6/11/5 and 6/6/7/5 sesterterpene scaffolds. Angewandte Chemie International Edition, 2018, 57(5), 1291-1295.
4.Huang, A.C.; Kautsar S. A..; Hong, Y. J.; Bond, A. D.; Madema M. H.; Tantillo, D. J.; Osbourn, A. Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveal convergent evolution. Proceedings of the National Academy of Science, U.S.A., 2017, 114(29), E6005-6014.
5.Huang, A.-C.; Sefton, M. A.; Sumby, C. J.; Tiekink, E. R.T.; Taylor, D. K. Mechanistic studies on the autoxidation of ?-guaiene: The structural diversity of the sesquiterpenoid downstream products. Journal of Natural Products, 2015, 78, 131-145.
6.Huang, A.-C.; Sefton, M. A.; Taylor, D. K. Comparison of the formation of peppery and woody sesquiterpenes derived from ?-guaiene and ?-bulnesene under aerial oxidative conditions. Journal of Agricultural and Food Chemistry, 2015, 63(8), 2137-2144
7.Huang, A.-C.; Sumby, C. J.; Tiekink, E. R.T.; Taylor, D. K. Synthesis of guaia-4(5)-en-11-ol, guaia-5(6)-en-11-ol, aciphyllene, 1-epi-melicodenone C and E and other guaiane-type sesquiterpenoids via the diastereoselective epoxidation of guaiol. Journal of Natural Products, 2014, 77(11), 2522-2536.
8.Huang, A.-C.; Burrett, S.; Sefton, M. A.; Taylor, D. K. Production of the pepper aroma compound, (-)-rotundone by aerial oxidation of α-guaiene. Journal of Agricultural and Food Chemistry, 2014, 62 (44), 10809–10815.
9.Huang, A.-C.; Wilde, A.; Ebmeyer, J.; Skouroumounis, G. K.; Taylor, D. K. Examination of the phenolic profile and antioxidant activity of the leaves of the Australian native plant Smilax glyciphylla. Journal of Natural Products, 2013, 76 (10), 1930-1936.
Non-first author publications:
10. Xue Z.; Tan Z.; Huang A.; Zhou Y.; Sun J.; Wang X.; Thimmappa R. B.; Stephenson M. J.; Osbourn A.; Qi X. Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species. New Phytologist. 2018, 218(3):1076-1088.
11. Owen C.; Patron N. J.; Huang A.; Osbourn A. Harnessing plant metabolic diversity. Current Opinion in Chemical Biology, 2017, 40, 24-30.
12. Nützmann H.-W.; Huang A.; Osbourn A. Plant metabolic clusters-from genetics to genomics. New Phytologist. 2016, 211(3), 711-789.
13. Davies, C; B?ttcher, C; Nicholson, E. L.; Burbidge, C. A.; Bastian, S; Harvey, K. E.; Huang, A.-C.; Taylor, D. K.; Boss, P. K. Shiraz wines made from grape berries (Vitis vinifera) delayed in ripening by plant growth regulator treatment have elevated rotundone levels and ‘pepper’ flavor and aroma. Journal of Agricultural and Food Chemistry, 2015, 63(8), 2137-2144.