個(gè)人簡(jiǎn)介：
南方科技大學(xué)醫(yī)學(xué)院研究助理教授,，于2013年從香港理工大學(xué)獲得博士學(xué)位,，之后先后于香港理工大學(xué)和南方科技大學(xué)從事博士后研究工作。主要研究方向?yàn)榻Y(jié)構(gòu)生物學(xué),、糖生物化學(xué)等,。
教育背景：
1999.9-2003.6 武漢大學(xué),，藥學(xué)專業(yè)，學(xué)士
2003.9-2006.6 武漢大學(xué),，藥物化學(xué),，碩士
2009.1-2013.10 香港理工大學(xué)，生物化學(xué)與分子生物學(xué)專業(yè),，博士
工作經(jīng)歷：
2006.07-2008.08 上海藥明康德新藥開發(fā)有限公司 藥物合成研究員
2013.10-2014.07 香港理工大學(xué),，研究助理
2014.07-2016.07 香港理工大學(xué)，博士后
2016.09-2019.05 南方科技大學(xué),，博士后
發(fā)表論文：
1. Shuai Wu # ,Yunjiao He#, Xianxiu Qiu,Wenchao Yang, Wenchao Liu, Xiaohua Li, Yan Li,Han-Ming Shen,Renxiao Wang, Zhenyu Yue, YanxiangZhao*. Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking. Proc Natl Acad Sci , 2018 Jun 19;115(25):E5669-E5678. (Co-first author)
2. Pan, Xuehua#; He, Yunjiao#; Chen, Tianfeng; Chan, Kin-Fai; Zhao, Yanxiang*, Modified Penicillin Molecule with Carbapenem- Like Stereochemistry Specifically Inhibits Class C beta-Lactamases. Antimicrobial Agents and Chemotherapy, 2017.12, 61(12). (Co-first author)
3. Pan, Xuehua; He, Yunjiao; Lei, Jinping; Huang, Xuhui; Zhao, Yanxiang*,，Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis. Journal of Biological Chemistry, 2017.3, 292(10): 4022~4033.
4. Pan, Xuehua; Wong, Wai-Ting; He, Yunjiao; Jiang, Yongwen; Zhao, Yanxiang*. Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 2014.8.26, 53(33): 5414~5423.
5. Teng H.; He Yunjiao.; Wu L.; Su J.; Feng X.; Qiu G.; Liang S.; Hu X*. A general and facile synthetic approach to N-alpha-Boc ureidoalanine derivatives. Synlett, 2006, (6): 877~880.
6. He Y, Lei J, Pan X, Huang X and Zhao Y. “Novel intermediates in the active site of Class A β-lactamase reveal critical factors that coordinate the catalytic water molecule for nucleophilic attack on β-lactam acyl adduct”. Scientific reports, 2019（Accepted）
專利：
Patent: 20061001876. Xianming Hu, Hanbing Teng, Yunjiao He. A Facile Synthetic Approach to Na-Boc Ureidoalanine Derivatives.
Patent number：9，潘雪華,，賀云嬌,，陳建輝，趙燕湘,，C類β-內(nèi)酰胺酶抑制劑及其制備方法和應(yīng)用,。
United States Patent Application 20180002381, Zhao, Yanxiang, WU, Shuai , Yang, Wenchao, HE, Yunjiao, LI, Xiaohua, Qiu, Xianxiu, Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation.
