師資
研究領域
◆細胞黏附蛋白在腎臟發(fā)育及相關疾病中的分子機制研究,;
◆細胞黏附蛋白在肺癌及乳腺癌發(fā)生發(fā)展和腫瘤轉移中的作用,;
◆腺苷在炎癥反應中的作用及其分子機制,。
工作經歷
2012.—至今 南方科技大學生物系 副教授,、 實驗動物中心副主任
2010-2012 香港科技大學,,博士后
教育背景
2010年,,香港科技大學生物系,,獲博士學位
2004年,南開大學微生物系,,獲碩士學位
2001年,,南開大學微生物系,獲學士學位
代表文章
1. Sun Y#*, Guo C#, Ma P, Lai Y, Yang F, Cai J, Sheng Y, Cheng Z, Tian R, Deng Y, Xiao G*, Wu C*. Kindlin-2 association with RhoGDIα suppresses Rac1 activation and podocyte injury. J Am Soc Nephrol. 2017 Aug 3; pii: ASN.2016091021.
2. Hu W#,,Yu X#, Liu Z#, Sun Y, Chen X, Yang X, Li X, Lam W, Duan Y, Cao X, Steller H, Liu K, Huang P. TRIP-Br1 mediates degradation of multiple adenylyl cyclase isoforms by XIAP E3 ligase. Elife,,2017 Jun 28;6. pii: e28021.
3. Sun Y*, Huang P*. Adenosine A2B receptor: from cell biology to human diseases. Front Chem. 2016 Aug 24;4:37. doi: 10.3389/fchem.2016
4. Sun Y#, Hu W#, Yu X, Liu Z, Tarran R, Ravid K, Huang P. Actinin-1 binds to the C-terminus of A2B adenosine receptor and enhances its cell surface expression. Biochem J. 2016 Jul 15;473(14):2179-86.
5. Xie C#, Cao X#, Chen X, Wang D, Zhang W, Sun Y, Hu W, Zhou Z, Wang Y, Huang P . Mechanosensitivity of wild-type and G551D cystic fibrosis transmembrane conductance regulator (CFTR) controls regulatory volume decrease in simple epithelia. FASEB J. 2016 Apr;30 (4):1579-89.
6.Sun Y, Duan Y, Eisenstein A, Hu W, Quintana A, Lam WK, Wang Y, Wu Z, Ravid, K, Huang P. A novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors. Journal of Cell Science, 2012 Oct 1;125(Pt 19):4507-17
7.Duan Y, Sun Y, Zhang F, Zhang W, Wang D, Wang Y, Hu W, Xie C, Cuppoleti J, Margin T, Wang H, Wu Z, Li N, Huang P. Keratin K18 increases CFTR surface expression by binding to its C-terminal hydrophobic patch. Journal of Biological Chemistry, 2012 Nov 23;287(48):40547-59.
8.Sun Y # , Wu F # , Sun F, and Huang P. Adenosine promotes IL-6 release in airway epithelia. Journal of Immunology, 2008 Mar 15;180(6):4173-81.
9.Wang D, Sun Y, Zhang W, and Huang P. Apical adenosine regulates basolateral Ca++-activated potassium channels in human airway Calu-3 epithelial cells. Am J of Physiol (Cell Physiology) 294, C1443-C1453, 2008
聯系方式
深圳市南山區(qū)西麗學苑大道1088號南方科技大學第一科研樓235室
郵編:518055
電子郵件:[email protected]